61:575
I-69
An Introduction to Genetic Analysis [Text] / Anthony J. F. Griffiths [et al.]. - 6th ed. - New York : Freeman W. H. and Company, 1996. - 916 p. - Bibliogr.: p. 851-859; Glossary: p. 859-880; Index: p. 901-916. - ISBN 0-7167-2604-1
MeSH-головна:
МОЛЕКУЛЯРНАЯ БИОЛОГИЯ -- MOLECULAR BIOLOGY (обучение)
ГЕНЕТИКА -- GENETICS (обучение)
Анотація: Two important genetic principles are depicted on the cover. First, most important cellular functions evolved many hundreds of millions of years ago. Second, the protein products of master control genes regulate the developmental fate of cells and tissues. A human disease called Aniridia—no iris in the eye—is represented in the pedigree. The bright spots on the human chromosomes indicate the location of the Aniridia gene. The DNA sequence of Aniridia reveals that it codes for a protein extremely similar to the protein of the eyeless gene in the fruit fly, Drosophila. Normally, the eyeless gene is expressed only in the tissue that will become the eye. If instead the eyeless gene is expressed in other tissues, those now develop into ectopic eyes, establishing the role of eyeless as a master control gene. If the human Aniridia gene is expressed in different tissues in Drosophila, then it also forces those other tissues to develop into eye. Thus, all available evidence points to the strong evolutionary conservation of these genes and the developmental pathways they control
Дод.точки доступу:
Griffiths, Anthony J. F.
Miller, Jeffrey H.
Suzuki, David T.
Lewontin, Richard C.
Примірників всього: 1
ІЛ (1)
Вільні: ІЛ (1)
|