Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells / O. O. Ratushna [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P88-89 MeSH-main: НОВООБРАЗОВАНИЯ -- NEOPLASMS ЭНДОПЛАЗМАТИЧЕСКОГО РЕТИКУЛУМА СТРЕСС -- ENDOPLASMIC RETICULUM STRESS Annotation: The endoplasmic reticulum (ER) stress represents the unfolded protein response to cope with the accumulation of unfolded or misfolded proteins. It is required to maintain the functional integrity of the ER, which is a dynamic intracellular organelle with exquisite sensitivity to alterations in homeostasis. The unfolded protein response is a key player in the development of different malignant tumors. Depending on the duration and severity of the ER stress, it leads to cell adaptation or demise. This stress is a fundamental phenomenon, which provides a secure protection of the cells from different environmental challenges and is transduced by three major ER resident stress sensors. Activation of these ER stress sensors leads to transcriptional reprogramming of the cells. The signaling pathways elicited by those stress sensors have connections with metabolic pathways and with other plasma membrane receptor signaling networks. As such, the ER has an essential position as a signal integrator in the cell and is instrumental in the different phases of tumor progression Additional Access Points: Ratushna, O.O. Minchenko, D.O. Riabovol, O.O. Luzina, O.Y. Minchenko, O.H. There are no free copies