Didenkul, N. V.     About the possibility of targeted prevention of calcitriol-associated pregnancy complications at the preclinical stage [Text] / N. V. Didenkul // Здоров’я жінки. - 2020. - № 4. - С. 47-50. - Бібліогр. в кінці ст. MeSH-main: БЕРЕМЕННОСТИ ОСЛОЖНЕНИЯ -- PREGNANCY COMPLICATIONS (лекарственная терапия, патофизиология, профилактика и контроль, этиология) ВИТАМИНА D НЕДОСТАТОЧНОСТЬ -- VITAMIN D DEFICIENCY (лекарственная терапия, осложнения, профилактика и контроль) ПЛАЦЕНТАРНАЯ НЕДОСТАТОЧНОСТЬ -- PLACENTAL INSUFFICIENCY (профилактика и контроль) КАЛЬЦИТРИОЛ -- CALCITRIOL (дефицит, терапевтическое применение) ВРЕМЯ ДО БЕРЕМЕННОСТИ -- TIME-TO-PREGNANCY Annotation: According to recent studies, in the vitamin D deficiency state (VDD), pregnancy can be complicated and the optimal level of VD in the blood is one of the conditions for the realization of reproductive potential During pregnancy, which occurred in conditions of VDD, the frequency of some pregnancy complications, including preeclampsia, the threat of miscarriage, placental dysfunction was in 2–4 times higher than in women with optimized VD status. One of the directions of the individual management plan for women with a negative obstetric history can be the determination of the level of VD in the blood and correction of the VDD at the preconception period. This approach is a pathogenetically substantiated and promising direction for the prevention of some pregnancy complications and improvement of perinatal outcomes There are no free copies