Stress during puberty facilitates precancerous prostate lesions in adult rats [Text] / D. Herrera-Covarrubias [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 4. - С. 269-275. - Bibliogr. at the end of the art. MeSH-main: БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL СТРЕСС ФИЗИОЛОГИЧЕСКИЙ -- STRESS, PHYSIOLOGICAL (действие лекарственных препаратов) ПОЛОВОЕ СОЗРЕВАНИЕ -- SEXUAL MATURATION (действие лекарственных препаратов) ЛИПОПОЛИСАХАРИДЫ -- LIPOPOLYSACCHARIDES (анализ) ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ БОЛЕЗНИ -- PROSTATIC DISEASES (патофизиология, этиология) СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL Annotation: Puberty can be a critical period for the long-term development of diseases, especially for stress-related disorders that depend on neuroendocrine and immune responses. Some organs like the prostate are prone to diseases that result from neuroendocrine or immune challenges, such as cancer. Aim: In the present study, we assessed the long-term effects of an acute pubertal stressor (immune-challenge) on the development of precancerous lesions in adult rats, and compared them with testosterone-induced prostatic lesions. Materials and Methods: Pubertal male rats received a single injection of lipopolysaccharide (LPS) or saline during puberty (5 weeks old). At adulthood (8 weeks old) males were subcutaneously implanted with either an empty capsule or filled with testosterone propionate (100 mg/kg). This resulted in a total of five groups: 1) intact untreated, 2) saline-treated and implanted with a blank capsule, 3) saline-treated and implanted with a testosterone capsule, 4) LPS-treated and implanted with a blank capsule, 5) LPS-treated and implanted with a testosterone capsule. Four weeks later, the rats were sacrified and their prostates processed for histology (hematoxylin and eosin stain) and blood serum processed for hormone analysis (testosterone and corticosterone). Results: Males treated with LPS (stressed during puberty via immune challenge) expressed epithelium dysplasia (specially in the ventral prostate), anisocytosis, presence of mononuclear cells, anisokariosis, non-basal polarity, abnormal nucleus-cytoplasm ratio, proplastic myoepithelium, and granular content in the lumen. These histological alterations were similar, but less severe than those observed in males implanted with testosterone during adulthood. Conclusion: These results indicate that pubertal exposure to an immune challenge (stress) facilitates the long-term development of prostatic lesions in adult male rats Additional Access Points: Herrera-Covarrubias, D. Coria-Avila, G. A. Hernandez, M. E. Ismail, N. There are no free copies