Type of document : Magazine article Edition cipher : Author(s) : Chekhun V. F., Lozovska Yu. V., Burlaka A. P., Ganusevich I. I., Shvets Yu. V., Lukyanova N. Yu., Todor I. M., Tregubova N. A., Naleskina L. A. Title : Remodulating effect of doxorubicin on the state of iron-containing proteins, and redox characteristics of tumor with allowance for its sensitivity to cytostatic agents Parallel titles :Ремодулювальний вплив доксорубіцину на кількісні показники залізовмісних протеїнів та редоксзалежні характеристики пухлини з урахуванням її чутливості до цитостатика Place of publication : Український біохімічний журнал. - 2016. - Т. 88, № 1. - С. 99-108 (Cipher УУ1/2016/88/1) Notes : Бібліогр.: в кінці ст. MeSH-main: БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER ДОКСОРУБИЦИН -- DOXORUBICIN ФЕРРИТИНЫ -- FERRITINS ТРАНСФЕРРИНЫ -- TRANSFERRINS КИСЛОРОДА АКТИВНЫЕ ФОРМЫ -- REACTIVE OXYGEN SPECIES Annotation: The study was aimed at determining the changes of metal-containing proteins in blood serum and tumor tissue of animals with parental and doxorubicin-resistant strains of Walker-256 carcinosarcoma before and after the cytostatic administration. It has been shown that upon doxorubicin action the levels of total iron and transferrin in the tissues from the both groups of animals decreased while that offerritine simultaneously increased with more pronounced pattern in the group of animals with resistant tumor strain. It has been shown that upon the action of doxorubicin in tumor tissue of animals with different sensitivity to the cytostatic there could be observed oppositely directed changes in the redox state of these cells that in turn determined the content of “free iron” complexes, ROS generation and concentration of active forms of matrix metalopro- teinase-2 and matrix metaloproteinase-9, namely, the increase of these indexes in animals with parental strain and their decrease in animals with the resistant one. So, our study has demonstrated the remodulating effect of doxorubicin on the state of metal-containing proteins and redox characteristics of tumor dependent on its sensitivity to cytostatic, at the levels of the tumor and an organism. These data may serve as a criterion for the development of programs for the correction of malfunction of iron metabolism aimed at elevating tumor sensitivity to cytostatic agents Additional Access Points: Chekhun, V. F. Lozovska, Yu. V. Burlaka, A. P. Ganusevich, I. I. Shvets, Yu. V. Lukyanova, N. Yu. Todor, I. M. Tregubova, N. A. Naleskina, L. A. |