Role of mitogen-activated protein kinase (МАРК) in processes of proliferation in human thyroid tumors [] = Роль митоген-активированной протеинкиназы (МАРК) в пролиферативных процессах в опухолях щитовидной железы человека / B. B. Guda [и др.] // Ендокринологія. - 2016. - Т. 21, № 1. - P5-9. - Библиогр. в конце ст. MeSH-головна: ЩИТОВИДНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- THYROID NEOPLASMS (иммунология, метаболизм, ультраструктура) НЕОПЛАСТИЧЕСКИЕ ПРОЦЕССЫ -- NEOPLASTIC PROCESSES МИТОГЕН-АКТИВИРОВАННЫЕ ПРОТЕИНКИНАЗЫ -- MITOGEN-ACTIVATED PROTEIN KINASES (иммунология, метаболизм, ультраструктура) ПРОЛИФЕРИРУЮЩИХ КЛЕТОК ЯДЕРНЫЙ АНТИГЕН -- PROLIFERATING CELL NUCLEAR ANTIGEN (иммунология, метаболизм, ультраструктура) Анотація: Effector kinase of the MAPK (mitogen-activated protein kinase)-pathway — extracellular signal-regulated kinase‑1/2 (ERK1/2) activation and expression and proliferating cell nuclear antigen (PCNA) content in normal tissues, benign and well-differentiated malignant (metastatic and not metastatic) human thyroid tumors were studied. In malignant tumors and tissue of follicular adenoma’s increased PCNA expression was observed, and the amount of antigen in tumor tissue, except for follicular carcinoma, exceeded the amount in the conditionally normal tissue. Importantly, in encapsulated papillary carcinomas this excess was 85%, while in non-encapsulated, metastatic tumors PCNA content was on average more than 3 times above normal, and in the cases of most aggressive tumors with metastases in lungs — even 4 times. PCNA amount in thyroid tissue could serve as one of diagnostic and prognostic markers, and development of effective antigen inhibitors may be a promising trend in thyroid cancer treatment Дод.точки доступу: Guda, B. B. Pushkarev, V. M. Pushkarev, V. V. Kovalenko, A. Ye. Taraschenko, Y. M. Zhuravel, V. Zinych, P. P. Zurnadzhy, L. Y. Kovzun, O. l. Tronko, M. D. Вільних прим. немає