Kopylchuk, G. P. Peculiarities of the free radical processes in rat liver mitochondria under toxic hepatitis on the background of alimentary protein deficiency [Text] = Особливості вільнорадикальних процесів у мітохондріях печінки щурів за токсичного гепатиту на тлі аліментарної протеїнової недостатності / G. P. Kopylchuk, O. M. Voloshchuk // Український біохімічний журнал. - 2016. - Т. 88, № 2. - P66-72. - Bibliogr. at the end of the art. MeSH-головна: БЕЛКОВО-ЭНЕРГЕТИЧЕСКАЯ НЕДОСТАТОЧНОСТЬ ПИЩЕВАЯ -- PROTEIN DEFICIENCY (метаболизм, осложнения) МИТОХОНДРИИ ПЕЧЕНИ -- MITOCHONDRIA, LIVER (метаболизм, патология) ПЕЧЕНИ ЛЕКАРСТВЕННОЕ ПОВРЕЖДЕНИЕ -- DRUG-INDUCED LIVER INJURY (метаболизм, этиология) КРЫСЫ -- RATS СВОБОДНЫЕ РАДИКАЛЫ -- FREE RADICALS (метаболизм) МИТОХОНДРИАЛЬНЫЕ БЕЛКИ -- MITOCHONDRIAL PROTEINS (метаболизм) Анотація: The rate of superoxide anion radical, hydroxyl radical and hydrogen peroxide generation, the level of oxidative modification of mitochondrial proteins in the liver of rats with toxic hepatitis was investigated on the background of alimentary protein deficiency. We did not find significant increases of the intensity of free radical processes in liver mitochondria of rats maintained on the protein-deficient ration. The most significant intensification of free radical processes in liver mitochondria is observed under the conditions of toxic hepatitis, induced on the background of alimentary protein deprivation. Under these conditions the aggravation of all studied forms of reactive oxygen species generation was observed in liver mitochondria. The generation rates were increased as follows: O2 – by 1.7 times, Н2О2 – by 1.5 times, •ОН – practically double on the background of accumulation of oxidized mitochondria-derived proteins. The established changes in thiol groups’ redox status of respiratory chain proteins insoluble in 0.05 M sodium-phosphate buffer (pH 11.5), and changes of their carbonyl derivatives content may be considered as one of the regulatory factors of mitochondrial energy-generating function Дод.точки доступу: Voloshchuk, O. M. Вільних прим. немає |