Disorders of carbohydrate metabolism in experimental brain injury [Text] / S. V. Ziablitsev [et al.] // Фізіологічний журнал. - 2016. - Т. 62, № 4. - P18-22 MeSH-головна: ЧЕРЕПНО-МОЗГОВЫЕ ТРАВМЫ -- CRANIOCEREBRAL TRAUMA (метаболизм) УГЛЕВОДНЫЙ ОБМЕН -- CARBOHYDRATE METABOLISM (физиология) ИНСУЛИН-СЕКРЕТИРУЮЩИЕ КЛЕТКИ -- INSULIN-SECRETING CELLS (метаболизм) ГЛЮКОЗА -- GLUCOSE (метаболизм) ИНСУЛИН -- INSULIN (метаболизм) МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL ЖИВОТНЫЕ ЛАБОРАТОРНЫЕ -- ANIMALS, LABORATORY Анотація: In experimental heavy closed brain injury (mortality in five days - 86%) it is shown that from the first hours the violations of carbohydrate metabolism in the form of triad were formed: the marked hyperglycemia (3.3-3.6 times), hyperinsulinemia (2.4-3.2 times) and insulin resistance (HOMA-indexes increased to 8.0-11.7 times). These changes were caused by a decrease in tissue sensitivity to insulin and were accompanied by decrease in functional activity of the pancreatic ?-cells. In total it is possible to consider these changes as a pentad of the typical disorders of carbohydrate metabolism at brain injury. Дод.точки доступу: Ziablitsev, S. V. Pishchnlina, S. V. Kolesnikova, S. V. Boris, R. N. Yuzkiv, Ya. S. Вільних прим. немає