Role of matrix metalloproteinase 9 and its tissue inhibitor 1 in development and prognosis of diabetic retinopathy [Text] / S. V. Ziablitsev [et al.] // Фізіологічний журнал. - 2016. - Том 62, N 5. - P37-44 MeSH-головна: ДИАБЕТИЧЕСКИЕ НЕФРОПАТИИ -- DIABETIC NEPHROPATHIES (диагностика, патофизиология) ИММУНОФЕРМЕНТНЫЕ МЕТОДЫ -- IMMUNOENZYME TECHNIQUES (методы) ПРОТЕОЛИЗ -- PROTEOLYSIS МАТРИКСА МЕТАЛЛОПРОТЕИНАЗА 9 -- MATRIX METALLOPROTEINASE 9 (анализ) ТКАНЕВОЙ ИНГИБИТОР МЕТАЛЛОПРОТЕИНАЗЫ-1 -- TISSUE INHIBITOR OF METALLOPROTEINASE-1 (анализ) ВОДЯНИСТАЯ ВЛАГА -- AQUEOUS HUMOR ПРОГНОЗ -- PROGNOSIS Анотація: The article presents the results of investigation of violations in the proteolysis system inpatients with type 2 diabetes and diabetic retinopathy (DR). We studied the levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in the blood and in the intraocular fluid of patients with type 2 diabetes depending upon the stage of DR. We have established that the level of MMP-9 and TIMP-1 in the blood and in the intraocular fluid increased in patients with type 2 diabetes without signs of DR and with any stage of DR compared to the levels of these parameters in patients without diabetes. Increasing the levels of MMP-9 and TIMP-1 took place with increasing of DR severity and reached its maximum levels at the proliferative stage of DR. It was found that the levels of MMP-9 in the intraocular fluid and type 2 diabetes duration affected the probability of developing diabetic macular edema. At the level of MMP-9?105 ng/ml and 2 diabetes duration ? 10 years, the probability of developing macular edema was 100%. As a result of the construction of predictive models it was found that the level of MMP-9 in the intraocular fluid, stage of DR at the beginning of observation and type 2 diabetes duration had influence on the probability of the development of proliferative DR over 4 years of follow-up. If the level of MMP-9 ?100 ng/ml, type 2 diabetes duration ? 10 years and absence of DR at the beginning of observation were observed the probability of developing proliferative DR would compose 85.9%. Дод.точки доступу: Ziablitsev, S. V. Korobova, А. V. Petrenko, О. V. Serduk, V. N. Mogilevsky, S. U. Вільних прим. немає