Gavriliuc, E. A.     New insights into atypical forms of chronic inflammatory demyelinating polyneuropathy [Text] / E. A. Gavriliuc // Український неврологічний журнал. - 2016. - N 4. - P18-25 MeSH-головна: ПОЛИНЕВРОПАТИИ -- POLYNEUROPATHIES (диагностика) МАЛОБЕРЦОВОГО НЕРВА НЕВРОПАТИИ -- PERONEAL NEUROPATHIES (патофизиология) МАЛОБЕРЦОВЫЙ НЕРВ -- PERONEAL NERVE (патология) НЕРВНЫХ ИМПУЛЬСОВ ПРОВЕДЕНИЕ -- NEURAL CONDUCTION БИОПСИЯ -- BIOPSY (методы) Анотація: Highlighting the clinical peculiarities of atypical chronic inflammatory demyelinating polyneuropathy (CIDP); comparative analysis of nerves conduction studies (NCS) parameters in typical and atypical CIDP; utility of somatosensory evoked potentials to demonstrate the proximal demyelination in pure sensory CIDP with normal NCS parameters; the role of superficial peroneal nerve biopsy in the diagnosis of CIDP. The study included 30 patients with atypical CIDP and 30 patients with typical CIDR All patients underwent NCS, Plood was drawn for biochemical tests, also electrophoresis and serum protein immunofixation. Peroneal nerve biopsy was performed in 9 patients (4 with atypical CIDP and 5 patients with typical CIDP). Overall Neuropathy Limitation Scale questionnaire (ONLS) was used for the assessment of functional disability in all patients. The mean value ONLS within atypical CIDP was 2,43 ± 0.29 points, lower compared to typical CIDP — 4.17 ± 0.24 points. Monoclonal gammopathies were found in 13 patients, representing 22% of patients with CIDP. Demyelinating criteria most frequently observed in the biopsy material is decreased number of myelinated thick fibers. NCS is not a gold standard for diagnosis atypical sensory CIDR According to ONLS scale, atypical CIDP are less disabling compared with typical CIDR Peroneal nerve biopsy within CIDP is performed only when electrophysiological studies do not elucidate demyelination criteria. Вільних прим. немає