Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines / N. Bezdieniezhnych [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P89-90 MeSH-головна: ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS ЦИТОКИНЫ -- CYTOKINES (действие лекарственных препаратов) ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМНЫЙ ПЕРЕХОД -- EPITHELIAL-MESENCHYMAL TRANSITION (действие лекарственных препаратов) Анотація: Formation of a highly malignant metastatic tumor cell phenotype and resistance to anticancer drugs are associated with the implementation of epithelial- mesenchymal transition (EMT). Thus, monitoring of EMT and the possible inhibition of this process could be helpful to inhibit the tumor progression. It is quite often that anti-tumor treatment is not effective, so new modalities and new targets to combat cancer should be developed. Established cell lines, primary cultures of malignant cells obtained from biopsies or ascites of patients with epithelial cancers (breast, colorectal and ovarian), immunohistochemistry, and statistical methods were used Дод.точки доступу: Bezdieniezhnych, N. Lykhova, O. Kocherga, R. Kudryavets, Yu. Вільних прим. немає