Search of protein kinase CK2 inhibitors based on purine-2,6-diones derivatives / M. V. Protopopov [et al.] // The Ukrainian Biochemical Journal. - 2017. - Том 89, N 5. - P32-39 MeSH-головна: ПРОТЕИНКИНАЗЫ -- PROTEIN KINASES (химия) Анотація: This work is aimed to the search of protein kinase CK2 inhibitors among the purine-2,6-dione derivatives by molecular docking and biochemical tests. It was found that the most active compound 8-[2-[(3-methoxyphenyl)methylidene]hydrazine-1-yl]-3-methyl-7-(3-phenoxypropyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione inhibited protein kinase CK2 with IC50 value of 8.5 µM in vitro in kinase assay. Biochemical tests and computer simulation results allowed determining the binding mode of the most active compound and structure-activity relationships Дод.точки доступу: Protopopov, M. V. Ostrynska, O. V. Ivanchenko, D. H. Starosyla, S. A. Bdzhola, V. G. Romanenko, M. I. Yarmoluk, S. M. Вільних прим. немає