Ethylthiosulfanilate effect on Candida tropicalis / L. B. Oriabinska [et al.] // The Ukrainian Biochemical Journal. - 2017. - Том 89, N 5. - P70-76 MeSH-головна: CANDIDA TROPICALES -- CANDIDA TROPICALIS (действие лекарственных препаратов) ПРОТИВОГРИБКОВЫЕ СРЕДСТВА -- ANTIFUNGAL AGENTS (терапевтическое применение) Анотація: The problem of resistance of microorganisms to antibiotics stimulates the search for new chemotherapy drugs. Ethylthiosulfanilate (ETS, S-ethyl 4-amino-benzenesulfonothioate, S-ethyl ester of 4-aminobenzenethiosulfoacid) as a structural analog of number of phytoncides was synthesized based on thiosulfoacid salts. ETS effect on opportunistic yeast fungi Candida tropicalis was studied. It was shown that ETS in subfungicidal concentration (125 µg/ml) affected some aspects of a constructive and energy metabolism of fungi: inhibited endogenous respiration and reduced the pool of nucleic acids. Additionaly the significant changes in lipogenesis of C. tropicalis were detected. It was established that ETS in fungistatic and subfungicidal concentrations possessed membranotropic effect and provided a high degree of cooperativity of structural transitions of membranes Дод.точки доступу: Oriabinska, L. B. Starovoitova, S. O. Vasylyuk, S. V. Novikov, V. P. Lubenets, V. I. Вільних прим. немає