The study of acute toxicity of 1,3-oxazole-4-il-phosphonic acid derivative in intraperitoneal administration [Текст] / I. V. Nizhenkovska [et al.] // Вісн. фармації. - 2018. - № 1. - С. 43-48 MeSH-головна: ОКСАЗОЛЫ -- OXAZOLES (фармакология, химический синтез) (фармакология, химический синтез) ТОКСИЧНОСТИ ОСТРОЙ ТЕСТЫ -- TOXICITY TESTS, ACUTE (использование, методы) ЛЕКАРСТВ ПУТИ ВВЕДЕНИЯ -- DRUG ADMINISTRATION ROUTES Анотація: The derivative of 1,3-oxazole-4-yl-phosphonic acid (OVP-1) has the vasodilatory activity and is studied as a potential antihypertensive agent. The toxicological assessment plays an important role in the preclinical study of new drugs It has been determined that LD50 of OVP-1 derivative in intraperitoneal administration to mice of both sexes is 3350.67 ± 54.62 mg/kg and belongs to the toxicity class VI – relatively harmless compounds, which makes this compound promising for further preclinical pharmacological studies Дод.точки доступу: Nizhenkovska, I. V. Sedko, V. K. Golovchenko, O. V. Golovchenko, O. I. Вільних прим. немає