The synthesis of mono-and bis-derivatives of spiro-2-oxindole[3,3’]pyrrole and the study of their antioxidant and anti-inflammatory activities [Текст] / Y. I. Syumka [et al.] // Вісн. фармації. - 2018. - № 3. - С. 5-13 MeSH-головна: ПИРРОЛЫ -- PYRROLES (химический синтез) СПИРОСОЕДИНЕНИЯ -- SPIRO COMPOUNDS (химический синтез) АНТИОКСИДАНТЫ -- ANTIOXIDANTS (химический синтез) ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL (химический синтез) СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP ИНДОЛЫ -- INDOLES (химический синтез) Анотація: To synthesize a series of mono- and bis-derivatives of spiro-2-oxindole[3,3’]pyrrole and study the antioxidant and anti-inflammatory activity of the compounds obtained Current research proved that the preparatory method, namely, the three-component cascade transformation of isatin, α-amino acids and dipolarophils based on bis-maleimides is effective for synthesis of spiro-2-oxindole[3,3']pyrrole mono- and bis-derivatives. Series of hexamethylene- and ethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-2a,5a'-dihydro-2,2',6'(1H,1'H,5'H)-trione) symmetric derivatives were obtained. The structure of the obtained compounds was confirmed. Investigation of the antioxidant properties of the synthesized compounds revealed the most active substances: 1'-(hexamethylene-N-maleimido)-5'-benzyl-2a',5a'-dihydro-1'H-spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-2,2',6'(1H,3'H,5'H)-trione 1; ethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-5'-methyl-2a,5a'-dihydro-2,2',6'(1H,1'H,5'H)-trione) 6; hexamethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-5'-benzyl-2a,5a'-dihydro-2,2',6(1H,1'H,5'H)-trione) 7. Compound 6 also showed anti-inflammatory properties on the reference drug level Дод.точки доступу: Syumka, Y. I. Kravchenko, A. B. Chernykh, V. P. Shemchuk, L. A. Вільних прим. немає