Predictive value and changes of inducible nitric oxide synthase expression in patients with rectal cancer under the influence of antitumor therapy [Текст] / V. V. Holotiuk [et al.]. - [Б. м. : б. в.] MeSH-головна: ПРЯМОЙ КИШКИ НОВООБРАЗОВАНИЯ -- RECTAL NEOPLASMS (лекарственная терапия) ЛУЧЕВАЯ ТЕРАПИЯ -- RADIOTHERAPY (использование) АРГИНИН -- ARGININE ФТОРАФУР -- TEGAFUR Анотація: The aim of investigation – to establish the features of iNOS expression in the rectum wall under the influence of various neoadjuvant therapy options in patients with rectal cancer (RC) and to find out its predictive significance. Materials and methods. In 88 patients with stage II–III rectal adenocarcinoma we established iNOS expression in the tumor before and after neoadjuvant radiotherapy (NRT), therapeutic pathomorphosis grade and density of immune cell infiltrates. Patients were divided into 3 groups: 1 – patients after the course of NRT on the tumor site; 2 – patients who underwent chemoradiomodification of the NRT with drug tegafur; 3 – patients who underwent chemoradiomodification of the NRT with tegafur and L-arginine. Results. In the tumors of rectal cancer the level of iNOS expression by 4.5 times exceeded that in the intact rectum wall (P 0.001), correlated with metastatic lesion of the regional lymph nodes (r Дод.точки доступу: Holotiuk, V. V. Kryzhanivska, A. Ye. Sadovyi, I. Ya. Tataryn, B. B.