Characteristics of immune status in children with cystic fibrosis [Text] / V. A. Klymenko [та ін.] // Клінічна імунологія. Алергологія. Інфектологія. - 2020. - N 2. - P63 MeSH-головна: КИСТОЗНЫЙ ФИБРОЗ -- CYSTIC FIBROSIS ДЕТИ -- CHILD ИММУННОЙ СИСТЕМЫ ПРОЦЕССЫ -- IMMUNE SYSTEM PROCESSES Анотація: The study was performed on 47 children with CF aged 0–17 years 11 months 29 days and 54 healthy children as control group in Kharkiv region. The CF diagnosis was based on clinical and paraclinical characteristics and positive results of pilocarpine test. It was found that for the Kharkiv region CF diagnosis median age was 8.0 (3.0; 24.0) months. The CFTR gene mutations were detected in 76.2% of children. Seven CFTR gene mutations were found: delF508–81,2%, N1303K, S1196X, del21kb, 711+1GА, Ratio132,721, Arg334Trp, W1282Х-3,1%. 28.5% patients have chronic Pseudomonas aeruginosa infection. Elevated levels of the CD3, CD16, CD25, phagocytosis of latex, circulating immune complexes, spontaneous nitroblue tetrazolium test, spontaneous index of activated neutrophils test, IgМ and decrease levels of the leukocytes, neutrophils, CD4, CD8, stimulated nitroblue tetrazolium test, lysosomal cationic proteins, IgА were found during the study of immune status in children with CF in comparison with a control group (p 0.05) Дод.точки доступу: Klymenko, V. A. Piontkovska, O. V. Drobova, N. M. Pasichnyk, O. V. Shelest, S. S. Вільних прим. немає