Novel approaches to correction of mitochondrial dysfunction and oxidative disorders in Parkinson’s disease [Text] / О. Gonchar [et al.] // Фізіологічний журнал. - 2019. - Том 65, N 3. - P61-72 MeSH-головна: ПАРКИНСОНА БОЛЕЗНЬ -- PARKINSON DISEASE (патофизиология) МИТОХОНДРИЙ ОБОРОТ -- MITOCHONDRIAL TURNOVER (физиология) КЛЕТКИ ФИЗИОЛОГИЧЕСКИЕ ПРОЦЕССЫ -- CELL PHYSIOLOGICAL PROCESSES (физиология) ЭЛЕКТРОНОВ ТРАНСПОРТ -- ELECTRON TRANSPORT (физиология) МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ ФАРМАКОЛОГИЧЕСКОГО ДЕЙСТВИЯ -- MOLECULAR MECHANISMS OF PHARMACOLOGICAL ACTION АНТИОКСИДАНТЫ -- ANTIOXIDANTS (метаболизм) ОБЗОР -- REVIEW Анотація: Mitochondrial dysfunction has been widely implicated in the neuronal degeneration in Parkinson’s disease (PD). The uses of mitochondria-targetedprotective compounds that prevent or minimize a wide range of mitochondrial defects constitute potential therapeutic strategies in the prevention and treatment of neuronal degeneration in PD. This review discusses the latest findings in this field obtained in PD patients and animal and cellular models ofPD with focusing on the effects ofpharmacological agents on mitochondrial biogenesis, fission, fusion, mitophagy machinery, and transcription of endogenous cytoprotective antioxidant enzymes. We have also presented the data concerning the technologies for research and screening novel bioactive molecules to target mitochondrial dysfunction in Parkinson’s disease Дод.точки доступу: Gonchar, О. Mankovska, I. Rozova, К. Bratus, L. Karaban, І. Вільних прим. немає