Telomere length, telomerase activity and oxidative stress in elderly with chronic cerebrovascular diseases [Text] / M. Cherska [et al.] // Пробл. ендокринної патології. - 2020. - N 2. - P81-88 MeSH-головна: АРТЕРИОСКЛЕРОЗ ГОЛОВНОГО МОЗГА -- INTRACRANIAL ARTERIOSCLEROSIS (метаболизм, патофизиология) ДИАБЕТ САХАРНЫЙ, ТИП 2 -- DIABETES MELLITUS, TYPE 2 (метаболизм, патофизиология) ПОЖИЛЫЕ -- AGED Анотація: Background. Clarification of the mechanisms of biochemical changes in the development of cerebrovascular diseases is the one of the main problems of modern medicine. The aim of our study is to determine the relationship of telomere length and telomerase activity with indicators of oxidative stress in patients with cerebral atherosclerosis (CA) and diabetes mellitus. Methods. The clinical and instrumental study involved 86 patients with CA. Results. The patients were divided twice into the 2 groups depending on the relative telomere length and telomerase activity. It has been found that the patients with CA with long telomeres have statistically significantly higher level of catalase (CAT) comparing to those from the group with short telomeres. Also, in the group with high telomerase activity the CAT and superoxide dismutase (SOD) levels are statistically significantly lower than in the group with low telomerase activity. It should be noted that the patients with long and short telomeres are comparable in age, and the age of the patients with low telomerase activity statistically significantly greater. Conclusions. In the patients with CA the association of some markers of oxidative stress (CAT, SOD, glutathione (GSH)) with telomere length and telomerase activity has been detected, regardless of the presence of concomitant diabetes mellitus. The most stable direct correlation in this category of the patients has been found between GSH and telomerase activity (r = 0.48), that may indicate the key role of GSH in the rate of telomere shortening and the development of atherosclerosis Дод.точки доступу: Cherska, M. Krasnienkov, D. Guryanov, V. Kukharskyy, V. Tronko, N. Kondratiuk, V. Zabuga, O. Вільних прим. немає