Hypoxic-hypercapnic environment as a model of hypometabolism, hypothermia, ‘voluntary’ calorie-restriction and non-medicamentous treatment of related pathology [Text] / D. A. Tolstun [та ін.] // Журнал неврології ім. Б.М. Маньковського. - 2021. - N 3. - P35 MeSH-головна: ИССЛЕДОВАТЕЛЬСКИЕ ТЕХНОЛОГИИ (ВНЕШ) -- INVESTIGATIVE TECHNIQUES (NON MESH) ОБМЕН ВЕЩЕСТВ -- METABOLISM (действие лекарственных препаратов, иммунология) ВОЗРАСТНЫЕ ФАКТОРЫ -- AGE FACTORS МЕДИЦИНА АЛЬТЕРНАТИВНАЯ -- COMPLEMENTARY THERAPIES (использование, методы) Анотація: Inverse relationship between aging and metabolic rate is well-documented in numerous phylogenetic and ontogenetic models. Of particular interest is comparison of two closely related murine species — mice and naked-mole rats (NMRs). The latter has significantly lower metabolic rate and body temperature and lives around an order of magnitude longer without development of age-associated pathology typical for mice and most other animal species. There are reasons to believe that the extraordinary longevity and resistance to pathology of NMRs are associated with hypoxic-hypercapnic environment (HHE) of their habitat. In this research we asked if HHE could induce similar changes in mice Дод.точки доступу: Tolstun, D. A. Knyazer, A. Dubiley, T. A. Tushinskaya, T. V. Pishel, I. N. Bezrukov, V. V. Fraifeld, V. E. Muradian, K. K. Вільних прим. немає