Brieieva, O.     Causes and consequences of genome instability in cancer / O. Brieieva // Онкологія. - 2021. - Т. 23, № 4. - P231 MeSH-головна: НОВООБРАЗОВАНИЯ -- NEOPLASMS (генетика, диагностика, патофизиология) ГЕНОМА НЕСТАБИЛЬНОСТЬ -- GENOMIC INSTABILITY Анотація: Genome instability is currently considered one of the main drivers of tumor heterogeneity, clonal evolution, and cancer progression. At present, a wide range of genetic and epigenetic abnormalities associated with different stages of oncogenesis have been identified. It is believed that many of them may influence disease prognosis and therapy efficiency. In tumor cells, lesions are detected at different levels of genome organization that manifests by changes in both structure and number of single nucleotides and chromosomes. Depending on the kind of genetic changes, there are several types of instability: nucleotide, microsatellite, and chromosomal. Recent studies have significantly deepened our understanding of factors leading to the development of different types of genome instability. Among these factors, abnormalities of DNA replication and repair, exo- and endogenous genotoxic influences, unequal distribution of genetic material during mitosis, and epigenetic modifications are considered the most significant. It is thought that mechanisms underlying genome instability may vary at different stages of oncogenesis. In addition, there is evidence of possible differences in the background of genetic changes and mutator phenotype in cells of patients with hereditary and sporadic forms of cancer. In particular, it is suggested that germline mutations in DNA repair and tumor suppressor genes play a key role in the development of genome instability in hereditary forms of cancer, whereas in sporadic tumors, such instability may be predominantly driven by replicative stress Вільних прим. немає