Форма документа : Стаття із журналу Шифр видання : Автор(и) : Shamelashvili K. L., Shtemenko N. I., Leus І. V., Babiy S. O., Shtemenko O. V. Назва : Changes in oxidative stress intensity in blood of tumor-bearing rats following different modes of administration of rhenium-platinum system Паралельн. назви :Зміни інтенсивності оксидативного стресу крові щурів-пухлиноносіїв за введення системи реній-платина різними способами Місце публікування : Український біохімічний журнал. - 2016. - Т. 88, № 4. - С. 29-39 (Шифр УУ1/2016/88/4) Примітки : Bibliogr. at the end of the art. MeSH-головна: БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL ОКСИДАТИВНЫЙ СТРЕСС -- OXIDATIVE STRESS ПЛАТИНЫ СОЕДИНЕНИЯ -- PLATINUM COMPOUNDS НОВООБРАЗОВАНИЯ ЭКСПЕРИМЕНТАЛЬНЫЕ -- NEOPLASMS, EXPERIMENTAL РЕНИЙ -- RHENIUM Анотація: Effects of the different modes of administration of dichlorotetra-μ-isobutyratodirhenium(III) -1 - (in water solution, liposomes, nanoliposomes and together with cisplatin - in the rhenium-platinum system) on the intensity of lipid peroxidation (LP) in blood plasma and the activity of the erythrocyte antioxidant enzymes were investigated on the model of tumor growth. A decrease in the concentration of TBA-active substances caused by dirhenium compounds was shown to be independent of the administration mode and the extent of the tumor growth inhibition. I was four-times more effective in inhibition of the LP burst than any known antioxidant. I induced the increasing activity of erythrocyte superoxide dismutase and decreasing activity of catalase. In vitro experiments with native superoxide dismutase, the interaction ofІ with following activation of the active center of the enzyme was confirmed and the superoxide dismutase activity of І was shown, that may contribute to the enhancement of the enzyme activity in vivo. The cluster rhenium compounds may be promising nontoxic potent antioxidants capable of deactivating superoxide radicals Дод.точки доступу: Shamelashvili, K. L. Shtemenko, N. I. Leus, І. V. Babiy, S. O. Shtemenko, O. V.