Форма документа : Стаття із журналу Шифр видання : Автор(и) : Ziablitsev S. V., Pishchnlina S. V., Kolesnikova S. V., Boris R. N., Yuzkiv Ya. S. Назва : Disorders of carbohydrate metabolism in experimental brain injury Місце публікування : Фізіологічний журнал. - К., 2016. - Т. 62, № 4. - С. 18-22 (Шифр ФУ6/2016/62/4) MeSH-головна: ЧЕРЕПНО-МОЗГОВЫЕ ТРАВМЫ -- CRANIOCEREBRAL TRAUMA УГЛЕВОДНЫЙ ОБМЕН -- CARBOHYDRATE METABOLISM ИНСУЛИН-СЕКРЕТИРУЮЩИЕ КЛЕТКИ -- INSULIN-SECRETING CELLS ГЛЮКОЗА -- GLUCOSE ИНСУЛИН -- INSULIN МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL ЖИВОТНЫЕ ЛАБОРАТОРНЫЕ -- ANIMALS, LABORATORY Анотація: In experimental heavy closed brain injury (mortality in five days - 86%) it is shown that from the first hours the violations of carbohydrate metabolism in the form of triad were formed: the marked hyperglycemia (3.3-3.6 times), hyperinsulinemia (2.4-3.2 times) and insulin resistance (HOMA-indexes increased to 8.0-11.7 times). These changes were caused by a decrease in tissue sensitivity to insulin and were accompanied by decrease in functional activity of the pancreatic ?-cells. In total it is possible to consider these changes as a pentad of the typical disorders of carbohydrate metabolism at brain injury. Дод.точки доступу: Ziablitsev, S. V. Pishchnlina, S. V. Kolesnikova, S. V. Boris, R. N. Yuzkiv, Ya. S.