Форма документа : Стаття із журналу Шифр видання : Автор(и) : Hamit Yasar Ellidag, Esin Eren, Mehmet Akdag, Ozlem, Kemal, Necat Назва : The relationship between serum ferritin levels and serum lipids and HDL function with respect to age and gender Паралельн. назви :Взаємозв’язок між рівнем сироваткових феритину, ліпідів і ліпопротеїнів високої щільності з урахуванням віку і статі людей Місце публікування : Український біохімічний журнал. - 2016. - Т. 88, № 6. - С. 76-86 (Шифр УУ1/2016/88/6) Примітки : Bibliogr. at the end of the art. MeSH-головна: ФЕРРИТИНЫ -- FERRITINS ЛИПИДНЫЙ ОБМЕН -- LIPID METABOLISM ВОЗРАСТНЫЕ ФАКТОРЫ -- AGE FACTORS ОБМЕНА ВЕЩЕСТВ БОЛЕЗНИ -- METABOLIC DISEASES ЛИПОПРОТЕИНЫ ВЫСОКОЙ ПЛОТНОСТИ -- LIPOPROTEINS, HDL ЛИПОПРОТЕИНЫ НИЗКОЙ ПЛОТНОСТИ -- LIPOPROTEINS, LDL Анотація: Elevated serum ferritin (SFer) levels have been associated with chronic diseases such as coronary heart disease and diabetes mellitus type 2. The aim of this study was to examine the relationship between SFer levels and serum lipid parameters, and how this relation changes in terms of age and gender. Additionally, we investigated a possible relationship between SFer levels and high-density lipoprotein (HDL) function. SFer levels and lipid panel (total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C) and HDL-C) of 4205 people (3139 women, 1066 men) were examined retrospectively. Study population was classified according to age and gender. Separately, 100 subjects (52 women, 48 men) were randomly recruited to investigate the relation between SFer levels, and HDL dependent paraoxonase-1 (PON1) and arylesterase (ARE) activities. In all age groups, women’s SFer levels were found to be significantly lower and HDL-C levels significantly higher compared to men. In the 50-70 ages range, TC and LDL-C levels of women were found to be significantly higher than those of men (P 0.01). SFer levels tended to increase with age in women. Correlation analyses revealed a negative correlation between levels of SFer and HDL-C, while positive correlations existed between levels of SFer, and TC, TG and LDL-C. There was no significant correlation between SFer levels and PON1 or ARE activities. The finding that increased SFer levels are accompanied by increased serum TC, TG and LDL-C levels may help us to explain the increased risk of metabolic disorders and cardiovascular disease in postmenopausal women Дод.точки доступу: Hamit, Yasar Ellidag Esin, Eren Mehmet, Akdag Ozlem Kemal Necat |