Форма документа : Стаття із журналу Шифр видання : Автор(и) : Nizhenkovska I. V., Sedko V. K., Golovchenko O. V., Golovchenko O. I. Назва : The study of acute toxicity of 1,3-oxazole-4-il-phosphonic acid derivative in intraperitoneal administration Місце публікування : Вісн. фармації. - Х., 2018. - № 1. - С. 43-48 (Шифр ВУ18/2018/1) MeSH-головна: ОКСАЗОЛЫ -- OXAZOLES ТОКСИЧНОСТИ ОСТРОЙ ТЕСТЫ -- TOXICITY TESTS, ACUTE ЛЕКАРСТВ ПУТИ ВВЕДЕНИЯ -- DRUG ADMINISTRATION ROUTES Анотація: The derivative of 1,3-oxazole-4-yl-phosphonic acid (OVP-1) has the vasodilatory activity and is studied as a potential antihypertensive agent. The toxicological assessment plays an important role in the preclinical study of new drugsIt has been determined that LD50 of OVP-1 derivative in intraperitoneal administration to mice of both sexes is 3350.67 ± 54.62 mg/kg and belongs to the toxicity class VI – relatively harmless compounds, which makes this compound promising for further preclinical pharmacological studies Дод.точки доступу: Nizhenkovska, I. V. Sedko, V. K. Golovchenko, O. V. Golovchenko, O. I.