Форма документа : Стаття із журналу Шифр видання : Автор(и) : Riabokon Yu. Yu., Tumanskiy V. A., Riabokon E. V. Назва : The interaction of morphological changes in the liver with the development of extrahepatic manifestations in patients with chronic hepatitis C Місце публікування : Патологія. - Запоріжжя, 2018. - Т. 15, N 1. - С. 45-48 (Шифр ПУ40/2018/15/1) MeSH-головна: ГЕПАТИТ C ХРОНИЧЕСКИЙ -- HEPATITIS C, CHRONIC ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY КРИОГЛОБУЛИНЫ -- CRYOGLOBULINS ЦИРРОЗЫ ПЕЧЕНИ -- LIVER CIRRHOSIS Анотація: The purpose of the work was to analyze the connections of morphological changes in the liver with the manifestation of clinical signs of extrahepatic manifestations in patients with CHC. Material and methods. The study included 86 patients with CHC. The correlation analysis of expressiveness degree of liver fibrosis and histological activity depending on the presence of clinical signs of extrahepatic manifestations of disease and changes of autoimmune parameters was carried out. Results. It was found that the incidence of mixed cryoglobulins in the blood of patients with CHC had a dependence on the de¬gree of fibrosis of the liver. In the presence of liver fibrosis F 3–4 mixed cryoglobulins were found in 94.2 % versus 64.7 % of patients with stages of liver fibrosis F 12 (P 0.01). In patients with stages of liver fibrosis F 3–4, the quantitative content of mixed cryoglobulins, RF-IgM and CIC was higher than those of patients with stages of liver fibrosis F 1–2. In patients with fibrosis in the liver F 3–4 cryoglobulinema incidence of vasculitis with formation of Meltzer’s triad was higher than in patients with liver fibrosis F 1–2 (19.2 % versus 2.9 %, P 0.05). Content of mixed cryoglobulins correlated with the degree of fibrosis of the liver (r Дод.точки доступу: Tumanskiy, V. A. Riabokon, E. V.