Форма документа : Стаття із журналу Шифр видання : Автор(и) : Shliakhtunou Ya. A. Назва : Expression of anti-apoptothic protein survivin and gene BIRC5 in primary breast carcinoma as a prognostic marker for progression of disease Місце публікування : Онкология. - Київ, 2018. - Том 20, N 4. - С. 255-259 (Шифр ОУ3/2018/20/4) Примітки : Бібліогр. наприкінці ст. MeSH-головна: МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS КАРЦИНОМА -- CARCINOMA ИНГИБИТОР БЕЛКОВ, РЕГУЛИРУЮЩИХ АПОПТОЗ -- INHIBITOR OF APOPTOSIS PROTEINS ПРОГНОЗ -- PROGNOSIS Анотація: Objective: to study the expression of anti-apoptotic protein survivin and its gene BIRC5 in primary breast carcinoma as a potential predictive and prognostic marker. Materials and methods. Using immunohistochemical methods and real-time polymerase chain reaction 67 samples (biopsy) of the primary breast carcinoma were studied for the presence of expression of survivin protein and its gene BIRC5. Results. Expression of survivin was determined in 47 (70.15 %) mammary carcinoma samples. Expression of survivin was most often determined in medium and high grade ductal carcinoma (G2–G3), and was associated with lymphovenous stromal invasion in most cases. Expression of survivin protein correlated with the expression of HER2/neu. In 59.6 % of cases survivin was expressed in tumors with a low Ki-67 index. Most often, survivin was expressed in luminal A and luminal B molecular-biological tumor subtypes. Real-time polymerase chain reaction determined the expression of BIRC5 gene in all 67 carcinoma samples. The level of normalized expression of BIRC5 gene significantly moderately correlated with the expression of its product – survivin protein (r = 0.704, p 0.01) and slightly correlated with the expression of oncoprotein HER2/neu (r