Форма документа : Стаття із журналу Шифр видання : Автор(и) : rasnoselkiy M. V., Krutko Ye. M., Protcenko E. S., Shulga Ye. V., Shulga M. V. Назва : Comparison of combined general anestesia with and without epidural morphine on the backgraund of redox therapy in cancer patients with multiorgan resections Паралельн. назви :Порівняння ефективності комбінованої анестезії з використанням епідурального морфіну та без нього на тлі корекції окисно-відновного метаболізму в онкохворих з мультиорганними оперативними втручаннями Місце публікування : Медицина невідкладних станів. - Київ, 2019. - N 6. - С. 69-75 (Шифр МУ104/2019/6) Примітки : Бібліогр. наприкінці ст. MeSH-головна: ЖЕЛУДОЧНО-КИШЕЧНОГО ТРАКТА НОВООБРАЗОВАНИЯ -- GASTROINTESTINAL NEOPLASMS ИНТРАОПЕРАЦИОННЫЙ КОНТРОЛЬ -- INTRAOPERATIVE CARE АНЕСТЕЗИЯ ЭПИДУРАЛЬНАЯ -- ANESTHESIA, EPIDURAL МОРФИН -- MORPHINE ПОСЛЕОПЕРАЦИОННОЕ ВЕДЕНИЕ БОЛЬНОГО -- POSTOPERATIVE CARE АНТИОКСИДАНТЫ -- ANTIOXIDANTS ЛЕЧЕНИЯ РЕЗУЛЬТАТОВ АНАЛИЗ -- TREATMENT OUTCOME Анотація: There are insufficient data on postoperative epidural anesthesia using morphine and conducting redox therapy in cancer patients with multiorgan resections with the assessment of immunological parameters. This work studies the intraoperative use of epidural morphine as compared with combined general epidural anesthesia, as well as the redox therapy in cancer patients with multiorgan resections with an evaluation of the indicators of immunity to provide anesthesia with advanced therapy of possible complications and obtain a more comfortable condition of patients. Materials and methods. The study examined 117 cancer patients with locally advanced tumor process of the gastrointestinal tract with multiorgan surgical interventions for health reasons (67.6 ± 3.7 years old). All patients were divided into four groups according to the type of anesthesia and type of antioxidant therapy. The groups with intraoperative epidural morphine use and without it were distinguished. L-ornithine L-aspartate with quercetin complex with povidone was used as an antioxidant therapy. The overall health-related quality of life was evaluated using the standard Short Health Status Assessment Questionnaire SF-36, using the evidence-based methodology. Results. The results suggest that in the group using epidural morphine, the degree of anesthesia effectiveness was sufficient, but there were registered the complications, including in the form of apnea while using morphine and a slight deterioration in immunity parameters. When applying the redox therapy, we have achieved improvement both in quality of life and more significantly in immunity. Conclusions. Thus, combined epidural anesthesia without morphine against the background of correction of redox metabolism in cancer patients with multiorgan resections is more comfortable for patients, less dangerous due to the lack of development of apnea, psychoemotional and economically justified, which indicates its priority using Дод.точки доступу: rasnoselkiy, M. V. Krutko, Ye. M. Protcenko, E. S. Shulga, Ye. V. Shulga, M. V.