Форма документа : Стаття із журналу Шифр видання : Автор(и) : Borysova T. P., Obolonska O. Yu. Назва : Influence of ibuprofen in closure of hemodynamically significant patent ductus arteriosus on the development of acute kidney injury in preterm infants Місце публікування : Медичні перспективи. - Д., 2021. - Т. 26, № 1. - С. 156-162 (Шифр МУ10/2021/26/1) Примітки : Bibliogr. at the end of the art. MeSH-головна: АРТЕРИАЛЬНОГО ПРОТОКА НЕЗАРАЩЕНИЕ -- DUCTUS ARTERIOSUS, PATENT ГЕМОДИНАМИКА -- HEMODYNAMICS МЛАДЕНЕЦ НЕДОНОШЕННЫЙ -- INFANT, PREMATURE ИБУПРОФЕН -- IBUPROFEN ПОЧЕК ОСТРОЕ ПОВРЕЖДЕНИЕ -- ACUTE KIDNEY INJURY Анотація: Premature infants with hemodynamically significant patent ductus arteriosus (HSPDA) have a high risk of developing acute kidney injury (AKI) due to renal hypoperfusion and use of ibuprofen for duct closure. The aim of the study was to evaluate the effect of ibuprofen for the closure of HSPDA on the development of AKI in preterm infants depending on high dose of the drug on the first day of life. 40 preterm infants with HSPDA who were admitted for observation on the first day of life were examined. To close the ductus arteriosus, infants received restrictive therapy. In addition, 32 (80,0%) preterm infants on the first day of life were prescribed ibuprofen: 19 infants – in high dose (20 mg/kg), 13 infants – in standard dose (10 mg/kg). Clinical examination and treatment of preterm infants was carried out according to the generally accepted methods. Echocardiography with Doppler was performed at 5-11 hours of life and then daily to determine the size and hemodynamic significance of patent ductus arteriosus. Diagnosis and stratification of the severity of AKI were performed according to the criteria of neonatal modification of KDIGO, for which the concentration of serum creatinine and diuresis were studied. According to the results of the study, it was established that the frequency of AKI on the third and fifth days of life in preterm infants with HSPDA, who received ibuprofen in a high dose (20 mg/kg) on the first day, was 73.7% and 84.2%, respectively, which is 2.2 (OR=5.6; CI: 1,43-21,95; р0.02) and 2.5 (OR Дод.точки доступу: Obolonska, O. Yu.