Форма документа : Стаття із журналу Шифр видання : Автор(и) : Ben Kridis W., Werda I., Mnejja W., Toumi N., Charfeddine I., Daoud J., Khanfir A. Назва : Therapeutic results of laryngeal preservation: a retrospective study Місце публікування : Experimental Oncology. - К., 2021. - Том 43, N 2. - С. 168-172 (Шифр ЕУ12/2021/43/2) MeSH-головна: ГОРТАНИ НОВООБРАЗОВАНИЯ -- LARYNGEAL NEOPLASMS ОРГАНОСОХРАНЯЮЩЕЕ ЛЕЧЕНИЕ -- ORGAN SPARING TREATMENTS Анотація: The objective of this study is to report the therapeutic results of the preservation strategy in locally advanced laryngeal cancers. Patients and Methods: Between January 2008 and December 2015, 24 patients with locoregional advanced non-metastatic laryngeal cancer (T2–4/N0–2) were collected retrospectively. Different therapeutic sequences were used: either induction chemotherapy followed by concurrent chemoradiotherapy or induction chemotherapy followed by radiotherapy or concurrent chemoradiotherapy or radiotherapy alone. Results: The objective response rate was 85.7%. Overall survival rates at 1 year, 3 years and 5 years were 91.3%, 80.2% and 53.5%, respectively. Administration of induction chemotherapy did not improve overall survival. The 1-year overall survival was 83.3% in the induction chemotherapy group vs 94.1% for those who did not received induction chemotherapy (p = 0.7). Conclusion: Our study showed the feasibility of this preservation strategy in clinical practice, with acceptable term toxicity Дод.точки доступу: Ben Kridis, W. Werda, I. Mnejja, W. Toumi, N. Charfeddine, I. Daoud, J. Khanfir, A.