The use of the Petri net method in the simulation modeling of mitochondrial swelling [Text] = Використання методології мереж Петрі для імітаційного моделювання набухання мітохондрій / Yu. V. Danylovych [et al.] // Український біохімічний журнал. - 2016. - Т. 88, № 4. - P66-74. - Bibliogr. at the end of the art. MeSH-главная: СПЕКТРОФОТОМЕТРИЯ -- SPECTROPHOTOMETRY (методы) МОЛЕКУЛЯРНОЙ СТЫКОВКИ МОДЕЛИРОВАНИЕ -- MOLECULAR DOCKING SIMULATION (использование, методы, тенденции) МИТОХОНДРИЙ НАБУХАНИЕ -- MITOCHONDRIAL SWELLING (иммунология, физиология) МОДЕЛИ БИОЛОГИЧЕСКИЕ -- MODELS, BIOLOGICAL БИОМЕДИЦИНСКИЕ ИССЛЕДОВАНИЯ -- BIOMEDICAL RESEARCH (тенденции) Аннотация: Using photon correlation spectroscopy, which allows investigating changes in the hydrodynamic diameter of the particles in suspension, it was shown that ultrahigh concentrations of Ca[[p]]2+[[/p]] (over 10 mM) induce swelling of isolated mitochondria. An increase in hydrodynamic diameter was caused by an increase of nonspecific mitochondrial membrane permeability to Ca ions, matrix Ca[[p]]2+[[/p]] overload, activation of ATP- and Ca[[p]]2+[[/p]]-sensitive K[[p]]+[[/p]]-channels, as well as activation of cyclosporine-sensitive permeability transition pore. To formalize the experimental data and to assess conformity of experimental results with theoretical predictions we developed a simulation model using the hybrid functional Petri net method Доп.точки доступа: Danylovych, Yu. V. Chunikhin, A. Y. Danylovych, G. V. Kolomiets, O. V. Свободных экз. нет