Molecular mechanisms of hepatopulmonary syndrome [Text] / I. Ya. Krynytska, M. I. Marushchak, I. M. Klishch // Фізіологічний журнал. - 2017. - Том 63, N 3. - P90-102 MeSH-главная: ПЕЧЕНИ БОЛЕЗНИ -- LIVER DISEASES (осложнения) ГЕПАТОПУЛЬМОНАЛЬНЫЙ СИНДРОМ -- HEPATOPULMONARY SYNDROME (патофизиология, эпидемиология, этиология) МОДЕЛИ МОЛЕКУЛЯРНЫЕ -- MODELS, MOLECULAR ОБЗОР -- REVIEW Аннотация: Hepatopulmonary syndrome (HPS) is a severe complication seen in advance liver disease. Its prevalence among cirrhotic patients varies from 4 to 47 percent. HPS exact pathogenesis remains unknown. In this review we summarized existing knowledge on the possible mechanisms and causes of the HPS. Pulmonary microvascular dilation and angiogenesis are two central pathogenic features that drive abnormal pulmonary gas exchange in experimental HPS, and thus might underlie HPS in humans. Despite these insights into the pathogenesis of experimental HPS, there is no established medical therapy, and liver transplantation remains the main treatment. Доп.точки доступа: Krynytska, I.Ya. Marushchak, M.I. Klishch, I.M. Свободных экз. нет