Determination of plasminogen/plasmin system components and indicators of lipoproteins oxidative modification under arterial hypertension / O. I. Yusova [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 1. - P58-67 MeSH-главная: ПЛАЗМИНОГЕНА АКТИВАТОР ТКАНЕВОГО ТИПА -- TISSUE PLASMINOGEN ACTIVATOR (метаболизм) ЛИПОПРОТЕИНЫ -- LIPOPROTEINS (метаболизм) ГИПЕРТЕНЗИЯ -- HYPERTENSION (диагностика, осложнения) Аннотация: The present study was investigated of levels of oxidative modification of lipoproteins and content of plasminogen/plasmin system components – tissue-type plasminogen activator (t-PA) and plasminogen activators inhibitor-1 (PAI-1), in patients with stage II arterial hypertension (AHT) and resistant form of AHT. It was established that t-PA level in blood plasma of the patients is 2 times lower under stage II hypertension than normal and 2.5 times lower under resistant AHT. The inhibitor activity is 1.5 and 2 times higher consequently. It is concluded that patients with AHT have a decreased fibrinolytic potential, which can cause thrombotic states. Our evaluation showed a significant accumulation of products of lipid and protein oxidation, decrease of activity of antioxidant enzymes and changes of the activity of high density-lipoproteins-associated enzymes (decrease of paraoxonase-1 activity, increase of myeloperoxidase activity). Oxidized lipoproteins, t-PA and PAI-1 can be used as prognostic markers of development of complications and for evaluating the efficacy of therapy in patients with arterial hypertension Доп.точки доступа: Yusova, O. I. Savchuk, O. V. Grinenko, T. V. Kuchmenko, O. B. Mhitaryan, L. S. Kupchins’ka, O. H. Yevstratova, I. N. Matova, O. O. Vasilinchuk, N. M. Drobot’ko, T. F. Свободных экз. нет