Long-term hypocholesterolemic effect of amidated alginate in rats [Text] / M. Marounek [et al.] // The Ukrainian Biochemical Journal. - 2018. - Том 90, N 6. - P120-125 MeSH-главная: ПЕЧЕНЬ -- LIVER (действие лекарственных препаратов) КРОВИ СЫВОРОТКА -- SERUM (действие лекарственных препаратов) АЛЬГИНАТЫ -- ALGINATES ХОЛЕСТЕРИН -- CHOLESTEROL ЖЕЛЧНЫЕ КИСЛОТЫ И СОЛИ -- BILE ACIDS AND SALTS ЭУКАРИОТЫ -- EUKARYOTA Аннотация: The effect of octadecylamide of alginic acid on blood serum and hepatic cholesterol, and the faecal output of fat and sterols was examined in female rats fed diets containing cholesterol and palm fat at 10 and 50 g/kg, respectively for 10 weeks. Amidated alginate, supplied at 10 and 20 g/kg, significantly decreased serum cholesterol from 5.25 to 2.99 and 2.39 µmol/ml, respectively, and decreased hepatic cholesterol from 30.7 to 12.3 and 9.4 µmol/g, respectively. Amidated alginate increased the faecal output of fat and at higher dosing significantly decreased faecal output of bile acids. Faecal output of bile acids and hepatic cholesterol significantly correlated (r = 0.791; P 0.001). The results of the present experiment showed that hypocholesterolemic effect of amidated alginate persisted within 10 weeks of feeding Доп.точки доступа: Marounek, M. Volek, Z. Taubner, T. Duskova, D. Kalachniuk, L. Свободных экз. нет