Инфекционные заболевания при беременности как фактор риска развития тяжелой преэклампсии [Текст] = Infectious diseases in pregnancy as a risk factor of development the heavy preeclampsia / Т. Е. Белокриницкая [та ін.] // Медичні аспекти здоров’я жінки. - 2020. - № 1. - С. 59-65. - Библиогр. в конце ст. MeSH-главная: ИНФЕКЦИОННЫЕ БОЛЕЗНИ -- COMMUNICABLE DISEASES (осложнения) ПРЕЭКЛАМПСИЯ -- PRE-ECLAMPSIA (этиология) БЕРЕМЕННОСТИ ОСЛОЖНЕНИЯ ИНФЕКЦИОННЫЕ -- PREGNANCY COMPLICATIONS, INFECTIOUS ФАКТОРЫ РИСКА -- RISK FACTORS Аннотация: Наши данные подтверждают, что острая инфекция у матери повышает риск развития преэклампсии более значимо, чем генетическая предрасположенность, ассоциированная с полиморфизмами тенов-кандидатов преэклампсии AGTR1-1166CC и NOS3-894TT. Таким образом, инфекционные заболевания во время беременности можно рассматривать как эпигенетический фактор риска развития тяжелой преэклампсии. Необходимы дальнейшие исследования, чтобы выяснить механизмы, лежащие в основе этой ассоциации The aim of the research. To study the association between the risk of severe preeclampsia developing and acute infectious processes in mothers-carriers of preeclampsia predictor genes AGTR1-1166CC and NOS3-894TT. Material and methods. A retrospective case-control study included 50 women with severe preeclampsia and 50 women in the comparison group. All patients were carriers of genetic polymorphisms AGTR1 -1166CC and NOS3-894TT, which are predictors of preeclampsia. The average age of pregnant women ranged from 20 to 35 years old. All women had a single-stage pregnancy, had no pre¬vious hypertension, kidney disease, cardiovascular, au¬toimmune, metabolic diseases, preeclampsia in the anamnesis. Genetic polymorphisms were studied by poly¬merase chain reaction with the detection of the amplifi¬cation product in real time. Statistical analysis included the calculation of x2, the odds ratio with its 95% of con¬fidence interval (95% Cl). Results. The risk of severe preeclampsia was signif¬icantly higher in women with asymptomatic bacte- riuria (OR = 17,0, 95% Cl 4,66-61,81), acute gesta¬tional pyelonephritis (OR = 5,4, 95% Cl 1,69-10,54), acute nonspecific bacterial vaginitis (OR = 6,7, 95% Cl 1,90-11,02), acute candidal vulvovaginitis (OR = 4,3, 95% Cl 1,45-9,99). Acute cytomegalovirus infection, toxoplasmosis, bacterial vaginosis were registered only in a group of patients with preeclampsia. Systemic in¬fectious diseases increase the probability of developing the severe preeclampsia in a greater extent (OR = 49,6, 95% Cl 13,05-188.64) than local infectious processes (OR = 4,5, 95% Cl 1,49-6,71). The conclusion. Our data confirm that acute infection in a mother increases the risk of developing pre-eclampsia more significantly than a genetic predisposition, asso-ciated with polymorphisms of candidate genes of pre¬eclampsia AGTR1-1166CC and NOS3-894TT. Thus, infectious diseases during pregnancy can be considered as an epigenetic risk factor for the development of severe preeclampsia. Further research is needed to find out the mechanisms of this association Доп.точки доступа: Белокриницкая, Т. Е. Фролова, Н. И. Колмакова, К. А. Плетнева, В. А. Свободных экз. нет