Antimicrobial, Antioxidant and some Biochemical Properties of Vaccinium vitis-idaea L. [Text] / M. V. Kryvtsova [et al.] // Мікробіологічний журнал. - 2019. - Том 81, N 3. - P40-52 MeSH-главная: РАСТЕНИЙ ЭКСТРАКТЫ -- PLANT EXTRACTS (химия) ФЛАВОНОИДЫ -- FLAVONOIDS (химия) Аннотация: Over the past years there has been a growing interest to vegetable raw materials evaluated from the viewpoint of their potential antimicrobial activity. Vaccinium genus plants are known to contain a whole spectrum of biologically active substances with anti-inflammatory, antidiabetic, gene-protective, antioxidant and antimicrobial properties. The purpose of the work was to study the antimicrobial, antioxidant and some biochemical properties of alcoholic extracts of fruit and leaves of Vaccinium vitis-idaea L., gathered in the Ukrainian Carpathians. Methods. The plants for the study were gathered around the village of Pylypets, Mizhhiria rayon, Zakarpatska oblast (Transcarpathia). From the fruit and leaves, ethyl and methyl extracts were produced. The subjects for study were their antioxidant activity (by DPPH method), total tannin and flavonoids (by spectrophotometric method), and antimicrobial activity (by diffusion-into-agar method). For the purpose of study, type and clinical isolates were used from the oral cavity of human patients suffering from inflammatory diseases of periodontium, characterized by wide resistance spectrum to antibiotics. Results. The reviewed extracts were observed to have a higher antimicrobial activity against Gram-positive bacteria. The highest antimicrobial activity was shown by the extract of Vaccinium vitis-idaea L. fruit. Its antimicrobial activity was registered upon both test and clinical isolates of S. aureus, including methicillin-resistant ones. The ethyl fruit extract and methanol leaf extract were established to show high antimicrobial effect upon S. pyogenes. The ethanol fruit and leaf extracts and methanol fruit extract were observed to show weak antimycotic activity. The extracts were characterized by high antioxidant activity, with the highest effect peculiar for ethyl leaf and fruit extracts, and somewhat lower one for methyl extracts. The ethanol fruit extract was characterized by the highest tannin level out of all extracts under review. Conclusions. The antimicrobial and high antioxidant activity of the ethanol extract of Vaccinium vitis-idaea L. fruit and leaves, and absence of the antimicrobial effect against the probiotic strain of Lactobacillus plantarum, characterized by the antagonistic activity against opportunistic microorganisms, cause the advisability of their complex application as the basis for phytobiotics Доп.точки доступа: Kryvtsova, M. V. Trush, K. Eftimova, J. Koscova, J. Spivak, M. J. Свободных экз. нет