Antonenko, S. V.     Phosphorylation of USP1 by BCR-ABLleads to deregulation of its functions and progression of chronic myeloid leukemia / S. V. Antonenko, D. S. Gurianov, G. D. Telegeev // Онкологія. - 2021. - Т. 23, № 4. - P230-231 MeSH-главная: ЛЕЙКОЗ МИЕЛОИДНЫЙ, ХРОНИЧЕСКАЯ ФАЗА -- LEUKEMIA, MYELOID, CHRONIC-PHASE (диагностика, метаболизм) ФОСФОРИЛИРОВАНИЕ -- PHOSPHORYLATION Аннотация: he development of chronic myeloid leukemia (CML) is associated with the appearance of the Bcr-Abl oncoprotein, which is formed as a result of reciprocal translocation between chromosomes 9 and 22. Due to the constitutive tyrosine kinase activity Bcr-Abl uncontrollably phosphorylates its protein partners. USP1 was identified as a potential partner for interaction with Bcr-Abl by mass spectrometric analysis. USP1 is a deubiquitinating protein that prevents proteosomal degradation of proteins, its’ dysfunction is typical for malignant cells. We believe that during the formation of the protein complex, Bcr-Abl kinase activates USP1 by phosphorylation, which promotes the accumulation of cancer protein in cells and the progression of CML Доп.точки доступа: Gurianov, D. S. Telegeev, G. D. Свободных экз. нет