Клинический случай гемолитической анемии в сочетании с вторичным хроническим пиелонефритом и внутриклеточной инфекцией у ребенка 7 лет [Текст] = Сlinical case of hemolytic anemia combined with secondary chronic pyelonephritis and intracellular infection in a 7-year-old child / И. Г. Самойленко [та ін.] // Здоровье ребёнка. - 2017. - N 3. - С. 109-113. - Библиогр. в конце ст. MeSH-главная: ДЕТИ -- CHILD ОПИСАНИЕ СЛУЧАЕВ -- CASE REPORTS АНЕМИЯ ГЕМОЛИТИЧЕСКАЯ ВРОЖДЕННАЯ -- ANEMIA, HEMOLYTIC, CONGENITAL (патофизиология, этиология) КОМОРБИДНОСТЬ -- COMORBIDITY ПИЕЛОНЕФРИТ -- PYELONEPHRITIS (патофизиология, терапия, этиология) ПОЗДНИЙ ДИАГНОЗ -- DELAYED DIAGNOSIS ВЫЗДОРОВЛЕНИЕ -- CONVALESCENCE (психология) Аннотация: В статье описан случай ранее не диагностированной гемолитической анемии у пациентки 7 лет, постановку правильного диагноза затрудняло наличие сопутствующих заболеваний. В результате обследования были выявлены: наследственная микросфероцитарная гемолитическая анемия Минковского — Шоффара, вторичный хронический обструктивный пиелонефрит и хроническая персистирующая внутриклеточная микст-инфекция Hemolytic anemias are group of diseases that are characterized by decreased lifetime of erythrocytes due to their accelerated destruction caused by membrane and enzymopathies of red blood cells, defects in globin synthesis or external factors such as intoxications and autoimmune processes. The most common hemolytic anemia in Europe is hereditary spherocytosis, which occurs in a ratio of 1 : 2000. Hereditary spherocytosis (Minkowski — Chauffard disease) is hereditary microspherocytic hemolytic anemia, which occurs as a result of mutation, leading to the erythrocyte membrane defect. Clinical manifestations of Minkowski — Chauffard anemia may vary from asymptomatic to fulminant hemolytic anemia, but commonly this disease has a undulant course. In our clinical practice, we observed hereditary spherocytosis combined with secondary chronic pyelonephritis and chronic persistent intracellular infection in a 7-year-old girl. The patient complained of high fever, general fatigue and weakness, and pain in the lower extremities. Complete doubling of the left kidney and urethra was diagnosed in a patient (her father has the same congenital pathology, which was diagnosed after the birth of his daughter) and refluxing megаureter of the lower half of left doubled kidney in the first year of her life. The girl underwent heminephroureterectomy on the left. Despite the surgical intervention, a secondary chronic pyelonephritis developed. Due to frequent anemia, patient was previously observed in the hematological department, but diagnosis of hemolytic anemia was not confirmed. Our clinical case shows that presence of concomitant diseases, especially chronic intracellular infection combined with pyelonephritis, can significantly complicate hemolytic anemia. Pale skin and mucous membranes are considered as a symptom of pyelonephritis, and ictericity is considered as a manifestation of liver damage with intracellular infection. As a result, more detailed examination and specific laboratory tests are not performed, and patient remains without adequate treatment for a long time, which significantly worsens his prognosis and quality of life Доп.точки доступа: Самойленко, И. Г. Долинский, В. В. Карпович, М. В. Павлов, Е. Н. Ткаченко, Е. В. Свободных экз. нет