Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure [Текст] / M. M. Kozub [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 3. - С. 181-185. - Bibliogr. at the end of the art. MeSH-главная: БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL ПЕРВИЧНАЯ ЯИЧНИКОВАЯ НЕДОСТАТОЧНОСТЬ -- PRIMARY OVARIAN INSUFFICIENCY (патофизиология, химически вызванный, этиология) КЛЕТОЧНАЯ И ТКАНЕВАЯ ТЕРАПИЯ -- CELL- AND TISSUE-BASED THERAPY (использование, статистика, тенденции) СТВОЛОВЫХ КЛЕТОК МЕЗЕНХИМНЫХ ТРАНСПЛАНТАЦИЯ -- MESENCHYMAL STEM CELL TRANSPLANTATION (использование, методы, статистика, тенденции) СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS Аннотация: About 1% of women suffer from premature ovarian failure, which leads to a significant deterioration in the life quality. Most often this condition is caused by performed chemotherapy, autoimmune diseases, surgery performed on ovaries, uterus, or fallopian tubes. The aim of this study was to compare different approaches of tissue and cell therapy in restoring the sexual function in case of ovarian failure induced by chemotherapy. Materials and Methods: The study was carried out in BALB/c mice with the modeled ovarian failure, induced by cyclophosphamide and busulfan. The restoration dynamics of ovarian and sexual function, liver and kidneys after application of cryopreserved explants, cryoextract, placental mesenchymal stem cells, those of adipose tissue has been studied. Results: It has been shown that the use of various methods of cell and tissue therapy has comparable efficacy when treating an ovarian failure induced by chemotherapy. The most rapid and complete restoration of the reproductive system, liver and kidneys was observed when using the placental explants, extract and cells, but not with the use of mesenchymal stem cells of adipose tissue. No recovery of fertility in this experiment was observed. Conclusion: Various methods of cellular and tissue therapy are perspective in treatment of the chemotherapy complications. More effective are placental derivates Доп.точки доступа: Kozub, M. M. Prokopiuk, V. Y. Skibina, K. R. Prokopiuk, О. V. Kozub, N. I. Свободных экз. нет