Aggregated proteins in malignant and benign neoplasms [Текст] / D. I. Zabolotnyi [та ін.] // Экспериментальная онкология. - 2019. - Т. 41, № 1. - С. 61-68. - Bibliogr. at the end of the art. Аннотация: To evaluate the presence of the aggregated proteins in malignant and benign neoplasms for clarifying the role of impaired protein metabolism in the formation of the altered tissues. Object and Methods: The histological specimens prepared from the operative materials of 196 patients with different forms of malignant and benign neoplasms were stained with Congo red and Thioflavin T and studied under the light and polarization microscope. Results: The various forms of β-stacked protein aggregates (β-SPA) inclusions were detected in amyloids, keloid tissue, benign polyps, and several malignant tumors. Conclusion: The formation of non-functional protein aggregates proves the complex character of the impairment of protein metabolism resulting in local or systemic accumulation of secondary protein toxins results in β-SPA formation as the self-sustaining complex of parametabolic processes. The β-SPA formation is of considerable interest since their properties lead to the impairment of the normal physiological processes in adjacent tissues ensuring the chronic course of the pathology Доп.точки доступа: Zabolotnyi, D. I. Belousova, A. A. Zabolotna, D. D. SavchenkoT., D. Voroshylova, N. M. Timchenko, M. D. Tsvirinko, I. R. Verevka, S. V. Свободных экз. нет