Вид документа : Статья из журнала Шифр издания : Автор(ы) : Pyrogova L. V., Chernyshenko T. M., Kolesnikova I. N., Platonova T. N., Bereznitsky G. K., Makogonenko Y. M., Lugovskoy E. V. Заглавие : Level of overall hemostasis potential in donor and patient plasma in pathology Параллельн. заглавия :Рівень загального гемостатичного потенціалу в плазмі крові донорів і пацієнтів із патологією Место публикации : Український біохімічний журнал. - 2016. - Т. 88, № 2. - С. 56-65 (Шифр УУ1/2016/88/2) Примечания : Bibliogr. at the end of the art. MeSH-главная: ПЛАЗМА -- PLASMA ФИБРИН -- FIBRIN ДОНОРЫ КРОВИ -- BLOOD DONORS ГЕМОСТАТИЧЕСКИЕ РАССТРОЙСТВА -- HEMOSTATIC DISORDERS КРОВЕНОСНЫХ СОСУДОВ БОЛЕЗНИ -- VASCULAR DISEASES Аннотация: Coagulation potential (CP), overall hemostasis potential (OHP) and fibrinolysis potential (FP) in plasma of donors and patients with myocardial infarction (MI), stroke (St) and hip joint diseases (HJD) have been investigated using M. Blomback’s global hemostasis assay. Plasma samples of the patients were analyzed with APTT reagent in the presence or absence of t-PA. It was found that the ratio of values of СP, OHP and FP in plasma of patients to those of donors plasma were 78, 60 and 123% at MI; 157, 155 and 162% at St; 128, 131 and 124% at HJD. CP to FP ratio that indicated balance between coagulation and fibrinolytic systems activities were 4.13, 2.5, 4.0 and 4.26 in plasma of donors and MI, St and HJD patients, respectively. These results are evidence of increased fibrinolytic activity in plasma of MI patients. Lag-periods of plasma clotting of MI, St and HJD patients were prolonged by 2.3, 7.2 and 1.5-fold, respectively. Pearson’s correlation analysis between parameters, obtained in vitro studies using global hemostasis assay, and concentrations of the molecular markers (soluble fibrin and D-dimer), which formed in vivo in plasma of MI, St and HJD patients, did not reveal any relationship between them Доп.точки доступа: Pyrogova, L. V. Chernyshenko, T. M. Kolesnikova, I. N. Platonova, T. N. Bereznitsky, G. K. Makogonenko, Y. M. Lugovskoy, E. V.