Вид документа : Статья из журнала Шифр издания : Автор(ы) : Brieieva O., Nesina I., Buchynska L. Заглавие : Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients Место публикации : Experimental Oncology. - К., 2017. - Том 39, N 1. - С. 93 (Шифр ЕУ12/2017/39/1) MeSH-главная: ЭНДОМЕТРИЯ НОВООБРАЗОВАНИЯ -- ENDOMETRIAL NEOPLASMS ГИДРОКСИЭСТРОНЫ -- HYDROXYESTRONES ЛИМФОЦИТЫ -- LYMPHOCYTES Аннотация: The endometrial cancer (EC) pathogenesis to a large extent may be determined by genotoxic effects of estrogen metabolites, among which the 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. Genomic instability and sensitivity to genotoxic estrogen metabolites in cells of EC patients depend on the DNA repair efficiency. The aim of the study was to analyze the level of DNA damage in peripheral blood lymphocytes (PBL) of EC patients after treatment with the 4OHE2 and to evaluate the repair efficiency of induced DNA damag Доп.точки доступа: Nesina, I. Buchynska, L.