Вид документа : Статья из журнала Шифр издания : Автор(ы) : Baiva P. P., Kovalenko Sv. M., Baranova I. I., Mamedova S. O. Заглавие : Development of the methods for the quantitative determination of fusidic acid and panthenol in the composition of “Fuzipam-derma” dermatological gel Место публикации : Вісн. фармації. - Х., 2018. - № 1. - С. 12-16 (Шифр ВУ18/2018/1) Предметные рубрики: Фузидиевая кислота MeSH-главная: ДЕРМАТОЛОГИЧЕСКИЕ СРЕДСТВА -- DERMATOLOGIC AGENTS ГЕЛИ -- GELS АКНЕ ОБЫКНОВЕННЫЕ -- ACNE VULGARIS Аннотация: To develop and validate the methods for the quantitative determination of fusidic acid and panthenol in “Fuzipam-derma” gel. Materials and methods. The determination was performed by high performance liquid chromatography (HPLC) according to the requirements of the State Pharmacopoeia of Ukraine (SPhU) 1.0 on a Prostar-210 liquid chromatograph, (Varian Chromatography System, USA). Results and discussion. The methods for the quantitative determination of fusidic acid and panthenol in “Fuzipam-derma” gel have been developed. The appropriate chromatographic conditions have been chosen, due to them the peaks of fusidic acid and panthenol are completely separated from other gel components. The validation of the methods for the quantitative determination of fusidic acid and panthenol has been performed. The data obtained have shown that the methods are stable and reproducible in different days. Conclusions. The methods for the quantitative determination of fusidic acid and panthenol in the composition of the new dermatological gel “Fuzipam-derma” for the treatment of grade І-ІІ acne has been developed using the HPLC method Доп.точки доступа: Baiva, P. P. Kovalenko, Sv. M. Baranova, I. I. Mamedova, S. O.