Вид документа : Статья из журнала Шифр издания : Автор(ы) : Kovalevska I. V., Ruban O. A., Grud’ko V. O. Заглавие : The spectrophotometric study of thioctic acid solutions to develop the method of its quantitative determination Место публикации : Вісн. фармації. - Х., 2018. - № 2. - С. 12-18 (Шифр ВУ18/2018/2) MeSH-главная: СПЕКТРОФОТОМЕТРИЯ -- SPECTROPHOTOMETRY ТИОКТОВАЯ КИСЛОТА -- THIOCTIC ACID АНТИОКСИДАНТЫ -- ANTIOXIDANTS Аннотация: Type II diabetes mellitus is a heterogeneous and multifactorial disease, which develops in the metabolic syndrome and significantly increases the risk of developing complications, such as angiopathy, neuropathy, retinopathy, nephropathy. Therefore, creation of new drugs that will affect all links of pathogenetic mechanism of the disease is presently topical. The main line treatment of the abovementioned pathologies is the use of antioxidant therapy. Antioxidants are important on different “lines of defense”: in the extracellular fluid, membrane and the cell cytosol. Thioctic acid belongs to these substances. The analysis of thioctic acid is of some difficulties as it has high propensity for different transformations, first of all, oxidation and polymerization. Therefore, the search of cost-neutral and at the same time rapid and effective methods of drug analysis remains relevant Доп.точки доступа: Ruban, O. A. Grud’ko, V. O.