Вид документа : Статья из журнала Шифр издания : Автор(ы) : Syumka Y. I., Kravchenko A. B., Chernykh V. P., Shemchuk L. A. Заглавие : The synthesis of mono-and bis-derivatives of spiro-2-oxindole[3,3’]pyrrole and the study of their antioxidant and anti-inflammatory activities Место публикации : Вісн. фармації. - Х., 2018. - № 3. - С. 5-13 (Шифр ВУ18/2018/3) MeSH-главная: ПИРРОЛЫ -- PYRROLES СПИРОСОЕДИНЕНИЯ -- SPIRO COMPOUNDS АНТИОКСИДАНТЫ -- ANTIOXIDANTS ПРОТИВОВОСПАЛИТЕЛЬНЫЕ СРЕДСТВА НЕСТЕРОИДНЫЕ -- ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL СТРУКТУРА-АКТИВНОСТЬ, ВЗАИМОСВЯЗЬ -- STRUCTURE-ACTIVITY RELATIONSHIP ИНДОЛЫ -- INDOLES Аннотация: To synthesize a series of mono- and bis-derivatives of spiro-2-oxindole[3,3’]pyrrole and study the antioxidant and anti-inflammatory activity of the compounds obtainedCurrent research proved that the preparatory method, namely, the three-component cascade transformation of isatin, α-amino acids and dipolarophils based on bis-maleimides is effective for synthesis of spiro-2-oxindole[3,3']pyrrole mono- and bis-derivatives. Series of hexamethylene- and ethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-2a,5a'-dihydro-2,2',6'(1H,1'H,5'H)-trione) symmetric derivatives were obtained. The structure of the obtained compounds was confirmed. Investigation of the antioxidant properties of the synthesized compounds revealed the most active substances: 1'-(hexamethylene-N-maleimido)-5'-benzyl-2a',5a'-dihydro-1'H-spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-2,2',6'(1H,3'H,5'H)-trione 1; ethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-5'-methyl-2a,5a'-dihydro-2,2',6'(1H,1'H,5'H)-trione) 6; hexamethylene-N,N'-bis(spiroindole-3,3'-pyrrolo[3,4-c]pyrrole-4'-nitroso-5'-benzyl-2a,5a'-dihydro-2,2',6(1H,1'H,5'H)-trione) 7. Compound 6 also showed anti-inflammatory properties on the reference drug level Доп.точки доступа: Syumka, Y. I. Kravchenko, A. B. Chernykh, V. P. Shemchuk, L. A.