Вид документа : Статья из журнала Шифр издания : Автор(ы) : Lamdan H., Garcia-Lazaro R. S., Lorenzo N., Galigiuri L. G., Alonso D. F., Farina H. G. Заглавие : Anti-proliferative effects of a blueberry extract on a panel of tumor cell lines of different origin Место публикации : Experimental Oncology. - К., 2020. - Том 42, N 2. - С. 101-108 (Шифр ЕУ12/2020/42/2) MeSH-главная: НОВООБРАЗОВАНИЙ КЛЕТКИ КУЛЬТИВИРУЕМЫЕ -- TUMOR CELLS, CULTURED ЧЕРНИКА -- HUCKLEBERRY PLANT Аннотация: Blueberries are among the fruits with the highest antioxidant activity and have been recognized by their health promoting properties. Aim: In vitro study of the anti-proliferative effects of a blueberry extract on a panel of cancer cells from different origin. Materials and Methods: A blueberry extract was produced using ethanol as extracting solvent. The anti-proliferative activity of the extract was evaluated against seven tumor cell lines. The properties of blueberry extract to decrease cell adhesion and migration were also investigated. Results: Blueberry extract showed a dose-dependent inhibitory effect on cell proliferation for all cell lines. Non-cytotoxic concentrations of the extract decreased cell adhesion in five of seven cell lines studied and inhibited the migration of MDA-MB-231 and PC-3 tumor cells. Conclusion: This work provides additional evidence regarding the ability of blueberry extract to inhibit the growth and decrease cell adhesion and migration of different cancer cell lines in vitro Доп.точки доступа: Lamdan, H. Garcia-Lazaro, R. S. Lorenzo, N. Galigiuri, L. G. Alonso, D. F. Farina, H. G.