Вид документа : Статья из журнала Шифр издания : Автор(ы) : Zabuha O. H., Vaiserman O. M. Заглавие : Developmental programming of tape 2 diabetes (theoretical background and experimental evidence) Место публикации : Журнал Національної академії медичних наук України. - К., 2019. - Том 25, N 1. - С. 88-92 (Шифр ЖУ3н/2019/25/1) MeSH-главная: ЭПИГЕНОМИКА -- EPIGENOMICS ГЕННОЙ ЭКСПРЕССИИ РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION ПИТАНИЕ НЕДОСТАТОЧНОЕ -- MALNUTRITION ПРЕНАТАЛЬНЫЙ ПЕРИОД, ВРЕДНОГО ВОЗДЕЙСТВИЯ ОТДАЛЕННЫЕ РЕЗУЛЬТАТЫ -- PRENATAL EXPOSURE DELAYED EFFECTS ДИАБЕТ САХАРНЫЙ, ТИП 2 -- DIABETES MELLITUS, TYPE 2 ДНК МЕТИЛИРОВАНИЕ -- DNA METHYLATION ОБЗОР -- REVIEW Аннотация: Consistent evidence from both theories and experimental studies suggest that inadequate nutrition in early life can contribute to risk for developing metabolic disorders, including type 2 diabetes (T2D) in adult life. Prenatal and/or early postnatal exposures to famine were demonstrated to be associated with higher risk of T2D in many cohorts around the world. Recent studies have highlighted the importance of epigenetic regulation of gene expression as a possible major contributor to a link between an early-life undernutrition exposure and T2D in adulthood. The findings from these studies suggest that a prenatal exposure to undernutrition may result in induction of persistent epigenetic changes that have adaptive significance in postnatal development but can predispose to metabolic disorders including T2D at the late stages of life. In this review, experimental data on the developmental programming of T2D are summarized and recent research findings on changes in DNA methylation that mediate these effects are discussed. Доп.точки доступа: Vaiserman, O. M.