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Title of magazine :Biomedical and Biosocial Anthropology -2021year,N 42
Interesting articles :
Oshurko A. P. Morphological features of bone tissue in "disuse atrophy" on the example of a segment of the human lower jaw: clinical experience of treatment/ A. P. Oshurko [та ін.] (стр.5-11)
Kulbitska V. V. Histological changes of the adrenal glands vessels after experimental thermal trauma and under the conditions of lyophilized xenoskin use/ V. V. Kulbitska (стр.12-17)
Malakhov V. O. Safety of transcranial magnetic stimulation in patients with multiple sclerosis/ V. O. Malakhov, P. K. Gaponov (стр.18-22)
Zykova N. P. Microscopic changes of the pancreas vessels in the dynamics after experimental thermal injury/ N. P. Zykova (стр.23-28)
Fedosieieva О. V. The effect of prenatal action of dexamethasone on morphological changes of the thyroid gland stromal compartment in juvenile rats/ О. V. Fedosieieva, V. S. Bushman (стр.29-33)
Ohinska N. V. Reorganization of cerebellar cortex structural components one day after experimental thermal injury/ N. V. Ohinska (стр.34-38)
Mostovoy Y. M. Features of the COPD course in patients with different alleles of C79G (rs1072714) of ADRB2 gene/ Y. М. Mostovoy, K. D. Dmytriiev, N. S. Slepchenko (стр.39-43)
Osovska N. Y. Associations of excess myocardial mass, echoreflectiveness and aldosterone synthase gene polymorphism in men with hypertension/ N. Y. Osovska [та ін.] (стр.44-51)
Bahrij D. A. Clinical significance of single nucleotide missense-mutation rs950880 of the IL1RL1 gene in patients with essential hypertension/ D. A. Bahrij (стр.52-46)
Malchenko О. V. In-depth investigation of analgesic activity of N-(4-methoxybenzyl)-4-methyl-2.2-dioxo-1H-2 λ6.1-benzothiazine-3-carboxamide derivate on different models of pain perception/ О. V. Malchenko (стр.57-63)
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2.

Type of document : Magazine article
Edition cipher :
Author(s) : Bahrij D. A.
Title : Clinical significance of single nucleotide missense-mutation rs950880 of the IL1RL1 gene in patients with essential hypertension
Place of publication : Biomedical and Biosocial Anthropology. - 2021. - № 42. - С. 52-46 (Cipher ВУ45/2021/42)
Notes : Bibliogr. at the end of the art.
MeSH-main: ПОЛИМОРФИЗМ ГЕНЕТИЧЕСКИЙ -- POLYMORPHISM, GENETIC
СЕРДЕЧНО-СОСУДИСТЫЕ БОЛЕЗНИ -- CARDIOVASCULAR DISEASES
МУЖЧИНЫ -- MEN
ГЕНЕТИЧЕСКИЕ МАРКЕРЫ -- GENETIC MARKERS
ДИАГРАММЫ -- CHARTS
ТАБЛИЦЫ -- TABLES
Geography headings: Подільський регіон
Annotation: Modern cardiology requires the search for specific pathogenetically involved gene mutations, the consequences of which can be considered in the management of patients with hypertension. Scientists are targeting C/A polymorphism at the rs950880 position, which is associated with tissue expression of the IL1RL1 gene and the plasma level of soluble ST2 – a new biomarker in the diagnosis of cardiovascular disease. The aim of the study was to evaluate the association of rs950880 polymorphism of the IL1RL1 gene and the state of central and intracardiac hemodynamics in men with essential hypertension (EН) of varying severity, residents of the Podillia region of Ukraine. 170 men who met the inclusion criteria were examined according to a standard protocol, which included clinical, laboratory and instrumental examinations in accordance with current recommendations. The subjects were divided into a control group of 70 men without cardiovascular disease and a study group of 50 men with asymptomatic EН and 50 people with EH complicated by IIA stage chronic heart failure (CHF). Genotyping of SNP rs950880 of the IL1RL1 gene was performed using an allele-specific polymerase chain reaction. All men in the control group and the study group underwent echocardiography with Doppler according to the standard protocol. Statistical processing of the obtained results was performed in the package Statistica 12.0 using conjugation tables analysis, analysis of variance. It was found that among men living in Vinnytsia, Ukraine, carriers of СС and CA SNP rs950880 of the IL1RL1 gene dominate (42.35 % and 45.30 % of individuals, respectively), AA homozygotes are significantly less common (12.53 %, p0.05). Men without cardiovascular diseases and patients with EH do not differ significantly in the frequency of different variants of the genotype of the studied gene. C\A polymorphism is not associated with the risk of EН. The homozygotes AA with EH have a significantly lower LV myocardial mass index (LVMMI) (69.14±6.90 g/m2.7, compared with homozygotes CC – 75.42±2.54 g/m2.7, and heterozygotes CA – 76.96±3.18 g/m2.7, p0.05). Among the carriers of the C allele, an "unfavorable" EН phenotype is mainly formed in the form of a high risk of LV hypertrophy (OR
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