Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Buchynska, L. G.
Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium [Text] / L. G. Buchynska, O. M. Movchan, N. P. Iurchenko // Experimental Oncology. - 2021. - Том 43, N 2. - P135-141

MeSH-main:
КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID (лекарственная терапия, метаболизм, патофизиология)
Annotation: The expression of the CXCL12 chemokine and its receptor CXCR4 in the stromal component of the tumor plays an important role in tumor cell migration, proliferation, inhibition of apoptosis and determination of invasive and metastatic potential of malignant neoplasms of various genesis. The significance of CXCL12 and CXCR4 expression in endometrial tumor cells for cancer progression is not fully understood. Aim: To evaluate the content of CXCL12+-fibroblasts and expression of CXCL12 and CXCR4 in endometrial cancer cells, depending on the tumor stage. Materials and Methods: Surgical material of 45 patients with endometrioid carcinoma of the endometrium (ECE) of the stages I–II and III was studied using morphological and immunohistochemical methods. Results: In ECE of stage I–II CXCR4 expression was lower (43.3 ± 4.2%) while CXCL12 expression was higher (33.6 ± 2.4%) compared with the corresponding indices in ECE of stage III (63.6 ± 3.5%, 24.5 ± 1.9%, respectively, p 0.05). In ECE of stage III, high expression of CXCR4 ( Me) and low CXCL12 ( Me) was observed in 80% of samples; these tumors invaded more than 1/2 of the myometrium. There was a positive correlation between the depth of tumor invasion in the myometrium and the presence of metastases and CXCR4 expression in tumor cells (R Me) (14.9 ± 1.3%) was detected. Conclusion: The obtained data reflect the communication of the immunosuppressive factor of the tumor microenvironment, i.e. CXCL12+-fibroblasts and CXCR4 expressing tumor cells. We suggest that the aggressiveness of ECE is determined by the combined effect of these two factors
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Movchan, O. M.
Iurchenko, N. P.

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Cipher: ЕУ12/2021/43/2
Journal

Экспериментальная онкология [Text]
2021year Т. 43 № 2

Contents:
Vitruk, Yu. V. Evaluation of response to tyrosine kinase inhibitors in renal cell carcinoma patients based on expression of miR-99b, -144, -210, -222, -302a and -377 in tumor tissue / Yu. V. Vitruk [et al.]. - С.98-103
Other authors: Semko S. L., Voylenko O. A., Pikul M. V., Borikun T. V., Zadvornyi T. V., Yalovenko T. M., Stakhovsky E. O., Rossylna O. V.
Pyaskovskaya, O. N. Role of tumor/endothelial cell interactions in tumor growth and metastasis / O. N. Pyaskovskaya [et al.]. - С.104-110
Other authors: Kolesnik D. L., Garmanchouk L. V., Yanish Yu. V., Solyanik G. I.
Akalovich, S. 5-FU resistens colorectal cancer cells possess improved invasiveness and β_III-tubulin expression / S. Akalovich [et al.]. - С.111-117
Other authors: Portyanko A., Pundik A., Mezheyeuski A., Doroshenko T.
Bychkov, V. A. In vitro modeling of tumor interclonal interactions using breast cancer cell lines / V. A. Bychkov [et al.]. - С.118-124
Other authors: Pevzner A. M., Nebova J. A., Ermakova N. N., Ibragimova M. K., Tsyganov M. M., Lyapunova L. S., Litviakov N. V.
Ayyildiz, A. Co-administration of apigenin with doxorubicin enhanges anti-migration and antiproliferative effects via PI3K/PTEN/AKT pathway in prostate cancer cells / A. Ayyildiz [et al.]. - С.125-134
Other authors: Koc H., Turkekul K., Erdogan S.
Buchynska, L. G. Expression of chemokine receptor CXCR4 in tumor cells and content of CXCL12+ -fibroblasts in endometrioid carcinoma of endometrium / L. G. Buchynska, O. M. Movchan, N. P. Iurchenko. - С.135-141
Yakovlev, P. G. Expression of TLR4 and major inflammatory cytokines in patients with bladder cancer of different grade and stage / P. G. Yakovlev [et al.]. - С.142-148
Other authors: Gorbach O. I., Ostapchenko L. I., Garmanchuk L. V., Skachkova O. V., Khranovska N. M., Senchylo N. V.
Zoubi, M. S. RAD51-UTR haplotype genetic polymorphisms and susceptibility to breast cancer in women from Jordanian population / M. S. Zoubi [et al.]. - С.149-154
Other authors: Al-Eitan L. N., Rababa D. M., Al-Batayneh K., Farzand R., Quinn G. A., Tambuwala M. M., Bakshi H. A.
Kornatska, A. G. A variant of TP53 gene (RS 1625895, 13494G>A) is associated with neoplasm localization in patients with uterine leiomyoma / A. G. Kornatska [et al.]. - С.155-158
Other authors: Flaksemberg M. A., Chubei G. V., Trokhymovych O. V., Rossokha Z. I., Fishchuk L. Ye., Medvedieva N. L., Vershyhora V. O., Gorovenko N. G.
Mohamed, Yusoff A. A. Significance of BRAFv600E mutation in intra-axial brain tumor in Malaysian patients: case series and literature review / A. A. Mohamed Yusoff [et al.]. - С.159-167
Other authors: Abd Radzak S. M., Mohd Khair S. Z. N., Abdullah J. M.
Ben, Kridis W. Therapeutic results of laryngeal preservation: a retrospective study / W. Ben Kridis [et al.]. - С.168-172
Other authors: Werda I., Mnejja W., Toumi N., Charfeddine I., Daoud J., Khanfir A.
Pilinska, M. A. Study of modifyng effects of astaxanthin on cytogenetic manifestations of bystander response in human peripheral blood lymphocytes in vitro / M. A. Pilinska [et al.]. - С.173-176
Other authors: Shemetun O. V., Talan O. O., Dibska O. B., Talko V. V.
De, Giorgi V. Scrotal cutaneous metastasis from rectal squamous cell carcinoma: a rare evolution into a rare tumor / V. De Giorgi [et al.]. - С.177-179
Other authors: Venturi F., Portelli F., Maida P., Scarfi F., Trane L., Gori A., Silvestri F., Massi D.
Liubota, R. Systemic chemotherapeutic treatment of patients with breast cancer brain metastases / R. Liubota [et al.]. - С.180-184
Other authors: Vereshchako R., Anikusko M., Liubota I., Vakulenko G.
Pasichnyk, S. M. Predicting changes in glomerular filtration rate in patients with kidney cancer using a mathematical model / S. M. Pasichnyk [et al.]. - С.185-188
Other authors: Pasichnyk M. S., Lychkovsky A. E., Stakhovsky E. O., Gozhenko A. I., Shatnyi S. V., Pasichnyk M. A.
Gluzman, D. F. Long-term exposure to low doses of ionizing radiation and COVID-19 pandemic: oncohematological aspects / D. F. Gluzman [et al.]. - С.189-192
Other authors: Zavelevich M. P., Philchenkov A. A., Koval S. V., Guslitser L. N., Zinchenko V. N., Bezhenar T. O.
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Buchynska, L. G.
Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina // Experimental Oncology. - 2019. - Том 41, N 4. - P335-341

Annotation: The aim of the study was to evaluate the morphological features of endometrioid carcinoma of the endometrium (ECE) of low differentiation grade with different invasive potential and to characterize their molecular phenotype by the expression of a number of adhesion markers. Materials and Methods: We have studied the samples of operation material of 37 patients with ECE of low differentiation grade with deep invasion ( ½ myometrium), n = 26, and with invasion ½ myometrium, n
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Naleskina, L. A.
Nesina, I. P.

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Cipher: ЕУ12/2019/41/2
Journal

Экспериментальная онкология [Text]
2019year Т. 41 № 2 . - 45.41, р.

Contents:
Verma, S. Evaluating the role of dithiolane rich fraction of Ferula asafoetida (apiaceae) for its antiproliferative and apoptotic properties: in vitro studies / S. Verma [та ін.]. - С.90-94. - Bibliogr. at the end of the art.
Other authors: Khambhala P., Joshi S., Kothari V., Patel T., Seshadri S.
Syvyk, A. E. Inducible dominant negative ErbB2 rat spermatogonial line for generation of transgenic rat model and dissecting ERBB2 tyrosine kinase mediated pathways / A. E. Syvyk, T. L. Syvyk. - С.95-105. - Bibliogr. at the end of the art.
Prylutska, S. V. Antitumor effects and hematotoxicity of C60-Cis-Pt nanocomplex in mice with Lewis lung carcinoma / S. V. Prylutska [та ін.]. - С.106-111. - Bibliogr. at the end of the art.
Other authors: Lynchak O. V., Kostjukov V. V., Evstigneev M. P., Remeniak O. V., Rybalchenko V. K., Prylutskyy Yu. I., Ritter U., Scharff P.
Petrellis, M. C. Proinflammatory effects of photoactivated methylene blue on rat model of Walker 256 carcinosarcoma / M. C. Petrellis [та ін.]. - С.112-122. - Bibliogr. at the end of the art.
Other authors: Frigo L., Ribeiro W., Leal-Junior E. C. P., Oliveira F. R., Maria D. A., Lopes-Martins R. Á. B.
Kolesnik, D. L. Metformin enhances antitumor action of sodium dichloroacetate against glioma C6 / D. L. Kolesnik [та ін.]. - С.123-129. - Bibliogr. at the end of the art.
Other authors: Pyaskovskaya O. N., Yurchenko O. V., Solyanik G. I.
Herrera-Covarrubias, D. Prepuberal stress and obesity: effects on serum corticosterone, prolactin, testosterone and precancerous prostate lesions in adult rats / D. Herrera-Covarrubias [та ін.]. - С.130-137. - Bibliogr. at the end of the art.
Other authors: Coria-Avila G. A., Aranda-Abreu G. E., Manzo J., Hernández M. E.
Buchynska, L. G. Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas / L. G. Buchynska, O. V. Brieiev, N. P. Iurchenko. - С.138-143. - Bibliogr. at the end of the art.
Kravets, O. V. Clinical and pathological prognostic factors in patients with stage III–IVA-B oral squamous cell carcinoma / O. V. Kravets [та ін.]. - С.144-147. - Bibliogr. at the end of the art.
Other authors: Protsyk V. S., Burtyn O. V., Hlynin O. V., Hurianov V. H.
Burlaka, A. P. Tumor-associated redox state in metastatic colorectal cancer / A. P. Burlaka [та ін.]. - С.148-152. - Bibliogr. at the end of the art.
Other authors: Ganusevich I. I., Burlaka A. A., Virko S. V., Kolesnik О. О.
Tajaldeen, A. Investigation of dosimetric impact of organ motion in static and dynamic conditions for three stereotactic ablative body radiotherapy techniques: 3D conformal radiotherapy, intensity modulated radiation therapy, and volumetric modulated arc therapy by usi / A. Tajaldeen, S. Alghamdi. - С.153-159. - Bibliogr. at the end of the art.
Yakovlev, P. G. Bladder sparing surgery in high-grade bladder cancer / P. G. Yakovlev, D. A. Klyushin, R. I. Vereshchako. - С.160-165. - Bibliogr. at the end of the art.
Cešeiko, R. The impact of maximal strength training on quality of life among women with breast cancer undergoing treatment / R. Cešeiko [та ін.]. - С.166-172. - Bibliogr. at the end of the art.
Other authors: Eglītis J., Srebnijs A., Timofejevs M., Purmalis E., Erts R., Vētra A., Tomsone S.
Ben, Kridis W. Prognostic factors in metastatic gastric carcinoma / Kridis W. Ben [та ін.]. - С.173-175. - Bibliogr. at the end of the art.
Other authors: Marrekchi G., Mzali R., Daoud J., Khanfir A.
Dumanskiy, Y. V. The Kі-67 marker for assessing the effectiveness of systemic or regional neoadjuvant polychemotherapy in patients with locally advanced breast cancer / Y. V. Dumanskiy, O. V. Bondar, E. A. Stoliarchuk. - С.176-178. - Bibliogr. at the end of the art.
Starchenko, I. I. The observation of congenital retroperitoneal large size neuroblastoma / I. I. Starchenko [та ін.]. - С.179-181. - Bibliogr. at the end of the art.
Other authors: Dyachenko L. V., Prylutskyi O. K., Vynnyk N. I., Filenko B. M.
Ben, Kridis W. Buschke — Lowenstein anal tumor: an ambiguous entity / Kridis W. Ben [та ін.]. - С.182-184. - Bibliogr. at the end of the art.
Other authors: Werda I., Charfi S., Toumi N., Boudawara T., Mzali R., Daoud J., Khanfir A.
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Buchynska, L. G.
Assessment of HER-2/neu, с-MYC and CCNE1 gene copy number variations and protein expression in endometrial carcinomas [Text] / L. G. Buchynska, O. V. Brieiev, N. P. Iurchenko // Экспериментальная онкология. - 2019. - Т. 41, № 2. - С. 138-143. - Bibliogr. at the end of the art.

Annotation: To analyze copy number variations of HER-2/neu, c-MYC and CCNE1 oncogenes and their protein expression in endometrioid endometrial carcinomas in relation to the degree of tumor progression and presence of a family history of cancer in cancer patients. Materials and Methods: The study was conducted on endometrial cancer (EC) samples from 68 patients with I–II FIGO stages of disease. Copy number analysis of HER-2/neu, c-MYC and CCNE1 genes was performed by quantitative PCR. Protein expression was analyzed using immunohistochemistry. Results: Assessment of copy number variations of HER-2/neu, c-MYC and CCNE1 genes revealed their amplification in the tumors of 18.8, 25.0 and 14.3% of EC patients, respectively. High expression of corresponding proteins was detected in 14.6, 23.5 and 65.6% of patients, respectively. It was established that HER-2/neu gene amplification is more common in the group of tumors of low differentiation grade than in moderate grade EC (35.7 and 5.5% of cases, respectively, p 0.05). Also, high expression of c-Myc protein was more frequently observed in low differentiated tumors compared to the moderately differentiated EC (36.6 and 13.2% of cases, respectively, p 0.05). Expression of HER-2/neu and cyclin E proteins was found to be dependent on the depth of tumor invasion into the myometrium. High expression of HER-2/neu protein was observed in 25.0 and 4.1% of EC patients with tumor invasion ½ and ½ of the myometrium, respectively, and cyclin E — in 86.7 and 46.6% of cases, respectively, p 0.05. It was shown that among patients with a family history of cancer, a larger proportion of cases with high expression of c-Myc protein was observed compared to the group of patients with sporadic tumors (43.8 and 17.3%, respectively; p 0.05). Conclusions: Amplification of HER-2/neu gene, along with high expression of c-Myc, HER-2/neu and cyclin E proteins, are associated with such indices of tumor progression as a low differentiation grade and deep myometrial invasion, suggesting the potential possibility of including these markers in the panel for determining the molecular EC subtype associated with an aggressive course of the disease. In a certain category of EC patients, there is a relationship between a family history of cancer and high expression of c-Myc protein
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Brieiev, O. V.
Iurchenko, N. P.

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Cipher: ЕУ12/2019/41/4
Journal

Экспериментальная онкология [Text]
2019year Т. 41 № 4 . - 45.41, р.

Contents:
Karaman, O. M. Macrophages - a perspective target for antineoplastic immunotherapy / O. M. Karaman, A. V. Ivanchenko, V. F. Chekhun. - С.282-290
Orel, V. E. Nоn-linear dynamics theory and malignant melanoma / V. E. Orel [et al.]. - С.291-299
Other authors: Korovin S. I., Molnair J., Orel V. B.
Lisyany, N. I. Cytomegaloviruses and malignant brain tumors / N. I. Lisyany [et al.]. - С.300-303
Other authors: Klyuchnikova A. A., Belskaya L. N., Lisyany A. A., Gnedkova I. A.
Woksepp, H. Proteomics of transforming growth factor β1 (TGF β1) signaling in 184A1 human breast epithelial cells suggests the involvement of casein kinase 2α in TGF β1-dependent p53 phosphorylation at Ser392 / H. Woksepp [et al.]. - С.304-311
Other authors: Saini R. K. R., Zakharchenko O., Gautier A., Souchelnytskyi N., Souchelnytskyi S.
Dehghan, Nayeri M. J. Apoptosis-inducing effect of spiroaminopyrimidine analogue in NB 4 leukemia cells via down-regulation of BIRC5 expression / Nayeri M. J. Dehghan [et al.]. - С.312-317
Other authors: Mahdavi M., Fazeli H., Hosseinpour Feizi M. A.
Albuquerque, A. P. B. Fut3 expression in human breast cancer cells under hypoxia and serum deprivation / A. P. B. Albuquerque [et al.]. - С.318-322
Other authors: Silva A. L. V., Lima C. A. D., Beltrao E. I. C.
Skuja, E. Deletions in metastatic colorectal cancer with chromothripsis / E. Skuja [et al.]. - С.323-327
Other authors: Butane D., Nakazawa-Miklasevica M., Daneberga Z., Purkalne G., Miklasevics E.
Burlaka, A. P. Molecular mechanisms of oxidation damage and liver cell dysfunction in patients with metastatic colorectal cancer / A. P. Burlaka [et al.]. - С.328-334
Other authors: Burlaka A. A., Virko S. V., Ganusevich I. I.
Buchynska, L. G. Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma / L. G. Buchynska, L. A. Naleskina, I. P. Nesina. - С.335-341
Zelinskaya, A. Immunocytochemical characteristics of thyrocytes in radioiodine refractory metastases of papillary thyroid cancer / A. Zelinskaya. - С.342-345
Moazeni-Roodi, A. Association bewtween XPO5 rs 1 1077 polymorphism and cancer susceptibility: a meta-analysis of 7284 cases and 85 1 1 controls / A. Moazeni-Roodi, M. Taheri, M. Hashemi. - С.346-352
Skrypnyk, I. How to improve quality of life in patients with acute leukemia and comorbid ischemic heart disease treated with anthracycline-based induction chemotherapy / I. Skrypnyk [et al.]. - С.353-356
Other authors: Maslova G., Lymanets T., Gusachenko I.
Gavars, D. Association of elevated vitamin B12 with oncohematological diseases in a cohort of 79, 524 patients from Lanvia / D. Gavars [et al.]. - С.357-362
Other authors: Perminov D., Tauckels E., Lindenberga I., Auce A., Lejniece S.
Prylutskyi, M. P. Detection of polyamines using immunobiosensor based on zinc oxide nanoparticles / M. P. Prylutskyi, M. F. Starodub. - С.363-365
Shkatula, P. M. International scientific conference "Tumor and Host: novel aspects of old problem" / P. M. Shkatula. - С.366-367
To the 120th birthday anniversary of academician R. E. Kavetsky. - С.368-369
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Cipher: ЕУ12/2018/40/3
Journal

Экспериментальная онкология [Text]
2018year Т. 40 № 3

Contents:
Akbarzadeh, A. Role of dendrimers in advanced drug delivery and biomedical applications: a review / A. Akbarzadeh [та ін.]. - С.178-183. - Bibliogr. at the end of the art.
Other authors: Khalilov R., Mostafavi E., Annabi N., Abasi E., Kafshdooz T., Herizchi R., Kavetskyy T., Saghfi S., Nasibova A., Davaran S.
Zadvornyi, T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro / T. V. Zadvornyi [та ін.]. - С.184-189. - Bibliogr. at the end of the art.
Other authors: Lukianova N. Y., Borikun T. V., Chekhun V. F.
Harper, P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies / P. Harper [та ін.]. - С.190-193. - Bibliogr. at the end of the art.
Other authors: Hald O., Lwaleed B. A., Kyyaly A., Johnston D., Cooper A. J., Birch B.
Apykhtina, О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles / О. L. Apykhtina [та ін.]. - С.194-199. - Bibliogr. at the end of the art.
Other authors: Dybkova S. M., Sokurenko L. M., Chaikovsky Yu. B.
Chekhun, V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats / V. F. Chekhun [та ін.]. - С.200-204. - Bibliogr. at the end of the art.
Other authors: Storchai D. M., Todor I. N., Borikun T. V., Lukianova N. Yu.
Prokhorova, I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6 / I. V. Prokhorova [та ін.]. - С.205-210. - Bibliogr. at the end of the art.
Other authors: Pyaskovskaya O. N., Kolesnik D. L., Solyanik G. I.
Abramenko, I. V. Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients / I. V. Abramenko [та ін.]. - С.211-217. - Bibliogr. at the end of the art.
Other authors: Bilous N. I. , Chumak A. A., Dyagil I. S., Martina Z. V.
Nesina, I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I. P. Nesina, N. P. Iurchenko, L. G. Buchynska. - С.218-222. - Bibliogr. at the end of the art.
Vernygorodskyi, S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction / S. Vernygorodskyi, T. Rekun, P. Zhuchenko. - С.223-227. - Bibliogr. at the end of the art.
Gerashchenko, T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles / T. S. Gerashchenko [та ін.]. - С.228-234. - Bibliogr. at the end of the art.
Other authors: Denisov E. V., Novikov N. M., Tashireva L. A., Kaigorodova E. V., Savelieva O. E., Zavyalova M. V., Cherdyntseva N. V., Perelmuter V. M.
Agishev, T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury / T. T. Agishev [та ін.]. - С.235-238. - Bibliogr. at the end of the art.
Other authors: Topuzov E. E., Кrasnozhon D. A., Petrachkov A. O., Pavlov R. V., Doniyarov S. H.
Dumansky, Yu. V. Paraneoplastic syndrome in lung cancer / Yu. V. Dumansky [та ін.]. - С.239-242. - Bibliogr. at the end of the art.
Other authors: Syniachenko O. V., Stepko P. A., Yehudina Ye. D., Stoliarova O. Yu.
Grybach, S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome / S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun. - С.243-248. - Bibliogr. at the end of the art.
Chrysanthakopoulos, N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study / N. A. Chrysanthakopoulos, N. S. Dareioti. - С.249-250. - Bibliogr. at the end of the art.
Tkachenko, R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy / R. Tkachenko, A. Golovko, O. Kuryk. - С.251-253
Svitlana Pavlivna Sidorenko (1953–2018). - С.254-255
Yurii Yosypovych Kudryavets (1946–2018). - С.256-257
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Cipher: ЕУ12/2018/40/1
Journal

Экспериментальная онкология [Text]
2018year Т. 40 № 1

Contents:
Kian, R. Role of components of microRNA machinery in carcinogenesis / R. Kian, S. Moradi, S. Ghorbian. - С.2-9. - Bibliogr. at the end of the art.
Patel, K. R. Clinical implications of p53 alterations in oral cancer progression: a review from India / K. R. Patel [та ін.]. - С.10-18. - Bibliogr. at the end of the art.
Other authors: Vajaria B. N., Singh R. D., Begum R., Patel P. S.
Varela-Castillo, O. Characterization of the cytotoxic effects of the combination of cisplatin and flavanol (-)-epicatechin on human lung cancer cell line A549. An isobolographic approach / O. Varela-Castillo [та ін.]. - С.19-23. - Bibliogr. at the end of the art.
Other authors: Cordero P., Gutierrez-Iglesias G., Palma I., Rubio-Gayosso I., Meaney E., Ramirez-Sanchez I., Villarreal F., Ceballos G., Najera N.
Chaves, K. C. B. Impact of endostatin gene therapy on myeloid-derived suppressor cells from a metastatic renal cell carcinoma / K. C. B. Chaves [та ін.]. - С.24-32. - Bibliogr. at the end of the art.
Other authors: Costa E. M., Teixeira L. F., Bellini M. H.
Sarnatskaya, V. V. Highly activated carbon enterosorbent mediates the suppression of paraneoplastic syndrome associated with lewis lung carcinoma in mice / V. V. Sarnatskaya [та ін.]. - С.33-41. - Bibliogr. at the end of the art.
Other authors: Sakhno L. A., Paziuk L. M., Yushko L. A., Rodionova N. K., Maslenny V. N., Sydorenko A. S., Nikolaev V.G.
Boroday, N. V. Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells / N. V. Boroday, V. F. Chekhun. - С.42-47. - Bibliogr. at the end of the art.
Kurtenkov, O. Signatures of anti-Thomsen — friedenreich antigen antibody diversity in colon cancer patients / O. Kurtenkov, M. Bubina, K. Klaamas. - С.48-58. - Bibliogr. at the end of the art.
Paliychuk, O. V. Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer / O. V. Paliychuk [та ін.]. - С.59-67. - Bibliogr. at the end of the art.
Other authors: Polishchuk L. Z., Rossokha Z. I., Chekhun V. F.
Buchynska, L. G. Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients / L. G. Buchynska, O. V. Brieieva. - С.68-72. - Bibliogr. at the end of the art.
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Symposium and Summer School “Fundamental principles of cancer biotherapy” Kyiv Ukraine May 21-24 2018. - С.88
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Buchynska, L. G.
Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients [Text] / L. G. Buchynska, O. V. Brieieva // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 68-72. - Bibliogr. at the end of the art.

MeSH-main:
НОВООБРАЗОВАНИЯ ГОРМОНОЗАВИСИМЫЕ -- NEOPLASMS, HORMONE-DEPENDENT (диагностика, патофизиология, этиология)
КАРЦИНОМА ЭНДОМЕТРИОИДНАЯ -- CARCINOMA, ENDOMETRIOID (патофизиология, этиология)
ЛИМФОЦИТЫ -- LYMPHOCYTES (цитология)
ДНК ПОВРЕЖДЕНИЕ -- DNA DAMAGE
РИСКА СТЕПЕНИ ОЦЕНКА -- RISK ADJUSTMENT (статистика, тенденции)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: The development of hormone-dependent cancers, including endometrial carcinomas, in great part may be mediated by the genotoxic effects of estrogen metabolites, among which 4-hydroxyestradiol (4OHE2) is characterized by the most prominent DNA-damaging properties. It is assumed that the individual sensitivity to the 4OHE2 may determine the predisposition to endometrial cancer (EС). Aim: To analyze the sensitivity of peripheral blood lymphocytes (PBLs) of EC patients to the 4OHE2 and to evaluate the repair efficiency of 4OHE2-induced DNA damage. Materials and Methods: The study was performed on the PBLs of 53 EC patients and 20 healthy women. The level of DNA damage was measured using the comet assay and was expressed as % tail DNA. The DNA repair efficiency (%) was evaluated by determining the ratio between the amount of repaired DNA damage and the level of 4OHE2-induced damage that appeared after incubation of PBLs with 4OHE2. Results: In PBLs of EC patients, a higher level of 4OHE2-induced DNA damage (32.0 ± 2.2% tail DNA) and lower DNA repair efficiency (34.0 ± 4.5%) was observed compared to PBLs of healthy women (22.3 ± 2.3% tail DNA and 48.8 ± 4.5%, respectively). PBLs of EC patients with deep tumor invasion of myometrium were characterized by more prominent decrease of DNA repair than those with less invasive tumor ( ½ of myometrium) (20.9 ± 7.8 and 43.7 ± 6.7%, respectively). Furthermore, lower DNA repair efficiency was detected in the PBLs of EC patients with a family history of cancer compared to this parameter in patients with sporadic tumors (20.9±7.8 and 47.1 ± 5.5%, respectively). Conclusion: The PBLs of EC patients are characterized by increased sensitivity to the genotoxic effect of 4OHE2 and reduced repair efficiency regarding 4OHE2-induced DNA damage. A lower level of DNA repair is observed in EC patients with deep tumor myometrial invasion and a family history of cancer
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Cipher: ЕУ12/2018/40/4
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Экспериментальная онкология [Text]
2018year Т. 40 № 4

Contents:
Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F Chekhun. - С.258-260
Tari, K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia / K. Tari [et al.]. - С.261-267
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Other authors: Fedosova N. I., Karaman O. M., Voyeykova I. M., Didenko G. V.
Yakymenko, I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation / I. Yakymenko [et al.]. - С.282-287
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Smal, M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer / M. P. Smal [et al.]. - С.288-298
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Buchynska, L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.]. - С.303-308
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Arabpour, F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients / F. Arabpour [et al.]. - С.309-314
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Gerashchenko, G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer / G. V. Gerashchenko [et al.]. - С.315-322
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Tas, F. Clinical significance of serum caveolin-1 levels in gastric cancer patients / F. Tas [et al.]. - С.323-327
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Shvachko, L. P. Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells / L. P. Shvachko [et al.]. - С.328-331
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Kuzyk, P. V. Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis / P. V. Kuzyk, M. A. Savchyna, S. G. Gychka. - С.332-335
Zakhartseva, L. M. Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart / L. M. Zakhartseva [et al.]. - С.336-342
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Langabeer, S. E. The JAK2 V617F mutation in lung cancer: caveat emptor / S. E. Langabeer. - С.343-344
Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary). - С.345
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