Бібліотека Вінницького національного медичного університету ім. М.І.Пирогова

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Remodulating effect of doxorubicin on the state of iron-containing proteins, and redox characteristics of tumor with allowance for its sensitivity to cytostatic agents [Text] = Ремодулювальний вплив доксорубіцину на кількісні показники залізовмісних протеїнів та редоксзалежні характеристики пухлини з урахуванням її чутливості до цитостатика / V. F. Chekhun [et al.] // Український біохімічний журнал. - 2016. - Т. 88, № 1. - P99-108. - Бібліогр.: в кінці ст.

MeSH-main:
БОЛЕЗНЬ, МОДЕЛИ НА ЖИВОТНЫХ -- DISEASE MODELS, ANIMAL
КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER (диагностика, кровь, патофизиология, ультраструктура, химия)
ДОКСОРУБИЦИН -- DOXORUBICIN (анализ, биосинтез, кровь, метаболизм, химия)
ФЕРРИТИНЫ -- FERRITINS (анализ, биосинтез, диагностическое применение, метаболизм)
ТРАНСФЕРРИНЫ -- TRANSFERRINS (анализ, биосинтез, диагностическое применение, метаболизм)
КИСЛОРОДА АКТИВНЫЕ ФОРМЫ -- REACTIVE OXYGEN SPECIES (анализ, метаболизм, химия)
Additional Access Points:
Chekhun, V. F.
Lozovska, Yu. V.
Burlaka, A. P.
Ganusevich, I. I.
Shvets, Yu. V.
Lukyanova, N. Yu.
Todor, I. M.
Tregubova, N. A.
Naleskina, L. A.

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Cipher: УУ1/2016/88/1
Journal

Український біохімічний журнал . - Published biomonthly
2016year Т. 88 № 1

Contents:
Uspenska, K. R. The effect of amixin and agmatine on cytochrome c release from isolated mitochondria / K. R. Uspenska [и др.]. - С.5-10. - Бібліогр.: в кінці ст.
Other authors: Gergalova G. L., Lykhmus O. Yu., Skok M. V.
Minchenko, O. H. Hypoxic regulation of the expression of cell proliferation related genes in U87 glioma cells upon inhibition of IRE1 signaling enzyme / O. H. Minchenko [и др.]. - С.11-21. - Бібліогр.: в кінці ст.
Other authors: Tsymbal D. O., Minchenko D. O., Riabovol O. O., Ratushna O. O., Karbovskyi L. L.
Sandeep, S. Multiple parametric approaches to assess acute radiation lung injury of rats / S. Sandeep [и др.]. - С.22-30. - Бібліогр.: в кінці ст.
Other authors: Mitra B., Priyanka A., Neeraj K., Aseem B., Neelam C.
Danylovych, H. V. Evaluation of functioning of mitochondrial electron transport chain with NADH and FAD autofluorescence / H. V. Danylovych. - С.31-43. - Бібліогр.: в кінці ст.
Franskevych, D. V. Modulation of cisplatin-induced reactive oxygen species production by fullerene C(60) in normal and transformed lymphoid cells / D. V. Franskevych [и др.]. - С.44-50. - Бібліогр.: в кінці ст.
Other authors: Grynyuk I. I., Prylutska S. V., Matyshevska O. P.
Kоbylinska, L. I. Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier / L. I. Kоbylinska [и др.]. - С.51-60. - Бібліогр.: в кінці ст.
Other authors: Havrylyuk D. Ya., Mitina N. E., Zаichenko A. S., Lesyk R. B., Zіmenkovsky B. S., Stoika R. S.
Rakhmetov, A. D. Prx II and CKBB proteins interaction under physiological and thermal stress conditions in A549 and HeLa cells / A. D. Rakhmetov [и др.]. - С.61-68. - Бібліогр.: в кінці ст.
Other authors: Lee Sang Pil, Ostapchenko L. I., Chae Ho Zoon
Olkhovych, N. V. Chitotriosidase activity as additional biomarker in the diagnosis of lysosomal storage diseases / N. V. Olkhovych. - С.69-78. - Бібліогр.: в кінці ст.
Gudkova, O. O. Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats / O. O. Gudkova, N. V. Latyshko, S. G. Shandrenko. - С.79-87. - Бібліогр.: в кінці ст.
Korneeva, K. L. Expression of genes, encoding the enzymes of cysteine metabolism in human placenta in the first and third trimesters of uncomplicated pregnancy / K. L. Korneeva [и др.]. - С.88-98. - Бібліогр.: в кінці ст.
Other authors: Rodriguez R. R., Ralchenko S. V., Martunovska O. V., Frolova A. О., Martsenyuk O. P., Manzhula L. V., Melnyk V. T., Shkoropad O. Y., Obolenska M. Yu.
Chekhun, V. F. Remodulating effect of doxorubicin on the state of iron-containing proteins, and redox characteristics of tumor with allowance for its sensitivity to cytostatic agents / V. F. Chekhun [и др.]. - С.99-108. - Бібліогр.: в кінці ст.
Other authors: Lozovska Yu. V., Burlaka A. P., Ganusevich I. I., Shvets Yu. V., Lukyanova N. Yu., Todor I. M., Tregubova N. A., Naleskina L. A.
Sokolik, V. V. Effect of β-amyloid peptide 42 on the dynamics of expression and formation of Аβ(40), IL-1β, TNFα, IL-6, IL-10 by peripheral blood mononuclear cells in vitro and its correction by curcumin / V. V. Sokolik, O. K. Koliada, S. M. Shulga. - С.109-118. - Бібліогр.: в кінці ст.
Bazalii, A. V. Transcriptional regulation of NOX genes expression in human breast adenocarcinoma MCF-7 cells is modulated by adaptor protein Ruk/CIN85 / A. V. Bazalii [и др.]. - С.119-125. - Бібліогр.: в кінці ст.
Other authors: Horak I. R., Pasichnyk G. V., Komisarenko S. V., Drobot L. B.
Данилова, В. М. Аналіз винахідницької діяльності відділу біохімії вітамінів і коензимів Інституту біохімії ім. О. В. Палладіна НАН України в 1980–2015 рр. / В. М. Данилова [и др.]. - С.126-140. - Бібліогр.: в кінці ст.
Other authors: Черниш І. Г., Виноградова Р. П., Луговська Г. Г., Юрасова С. П.
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Cipher: ЕУ12/2017/39/3
Journal

Экспериментальная онкология [Text]
2017year Т. 39 № 3 . - 34.76, р.

Contents:
Chekhun, V. F. On the 40th anniversary of the international symposium “The role of stem cells in leukemo-and carcinogenesis»: in Kyiv again / V. F. Chekhun. - С.162-163
Kalynychenko, T. O. Umbilical cord blood banking in the worldwide hematopoietic stem cell transplantation system: perspectives for Ukraine / T. O. Kalynychenko. - С.164-170. - Bibliogr. at the end of the art.
Vasyliev, R. G. Large-scale expansion and characterization of human adult neural crest-derived multipotent stem cells from hair follicle for regenerative medicine applications / R. G. Vasyliev [та ін.]. - С.171-180. - Bibliogr. at the end of the art.
Other authors: Rodnichenko A. E., Gubar O. S., Zlatska A. V., Gordiienko I. M., Novikova S. N., Zubov D. O.
Kozub, M. M. Comparison of various tissue and cell therapy approaches when restoring ovarian, hepatic and kidney’s function after chemotherapy-induced ovarian failure / M. M. Kozub [та ін.]. - С.181-185. - Bibliogr. at the end of the art.
Other authors: Prokopiuk V. Y., Skibina K. R., Prokopiuk О. V., Kozub N. I.
Gubar, O. S. Postnatal extra-embryonic tissues as a source of multiple cell types for regenerative medicine applications / O. S. Gubar [та ін.]. - С.186-190. - Bibliogr. at the end of the art.
Other authors: Rodnichenko A. E., Vasyliev R. G., Zlatska A. V., Zubov D. O.
Vasyliev, R. G. Tissue-engineered bone for treatment of combat related limb injuries / R. G. Vasyliev [та ін.]. - С.191-196. - Bibliogr. at the end of the art.
Other authors: Oksymets V. M., Rodnichenko A. E., Zlatska A. V., Gubar O. S., Gordiienko I. M., Zubov D. O.
Zlatska, A. V. Endometrial stromal cells: isolation, expansion, morphological and functional properties / A. V. Zlatska [та ін.]. - С.197-202. - Bibliogr. at the end of the art.
Other authors: Rodnichenko A. E., Gubar O. S., Zubov D. O., Novikova S. N., Vasyliev R. G.
Chekhun, V. F. Association of CD44⁺CD24^-/low with markers of aggressiveness and plasticity of cell lines and tumors of patients with breast cancer / V. F. Chekhun [та ін.]. - С.203-211. - Bibliogr. at the end of the art.
Other authors: Lukianova N. Y., Chekhun S. V., Bezdieniezhnykh N. O., Zadvomiy T. V., Borikun T. V., Polishchuk L. Z., Klyusov O. M.
Karlitepe, A. Anti-cancer efficiency of natural killer cells differentiated from human adipose tissue-derived mesenchymal stem cells and transfected with miRNA150 / A. Karlitepe [та ін.]. - С.212-218. - Bibliogr. at the end of the art.
Other authors: Kabadayi H., Vatansever S., Gurdal M., Gunduz C., Ercan G.
Lisyaniy, N. I. Content of stem tumor CD133⁺ cells in brain neoplasms of different histological type / N. I. Lisyaniy [та ін.]. - С.219-223. - Bibliogr. at the end of the art.
Other authors: Stanetskaya D. N., Lisyaniy A. N., Belskaya L. N.
Ryspayeva, D. E. Are CD44⁺CD24^- cells the assumed cancer stem cells in breast cancer? / D. E. Ryspayeva [та ін.]. - С.224-228. - Bibliogr. at the end of the art.
Other authors: Smolanka I. I., Dudnichenko A. S., Lyashenko A. A., Grinevich Yu. A., Gurianov V. G., Koshubarova M. V., Seleznev A. A.
Bezdieniezhnykh, N. O. Scientific-practical and legal problems of implementation of the personalized medicine / N. O. Bezdieniezhnykh, V. V. Reznikova, O. V. Rossylna. - С.229-233
Normal and cancer stem cells: discovery diagnosis and therapy international scientific conference. R. E. Kavetsky Institute of Experimental Pathology Oncology and Radiobiology National Academy of Sciences of Ukraine Kyiv October 5–6 2017. - С.234-256
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Complexes of palladium(II) with 1-phenyl-1-hydroxymethylene bisphosphonic acid and their antitumor activity / O. M. Kozachkova [et al.] // The Ukrainian Biochemical Journal. - 2017. - Том 89, N 2. - P106-115

MeSH-main:
ПРОТИВООПУХОЛЕВЫЕ СРЕДСТВА -- ANTINEOPLASTIC AGENTS (терапевтическое применение)
ПАЛЛАДИЙ -- PALLADIUM (терапевтическое применение)
Annotation: Complex formation of K₂[PdCl₄] with 1-phenyl-1-hydroxymethylene bisphosphonic acid (PhHMBP, H₄L) has been studied by pH potentiometry, electron and NMR spectroscopy. It was found that in aqueous solution with physiological concentration of chlorine anions (0.15 mol/l KCl), anionic complexes of the equimolar compositions [PdHLCl₂]^3- (lgβ = 24.51 (0.3)) and [PdLCl₂]^4-(lgβ = 20.74 (0.02)) are formed. In the first coordination sphere palladium was surrounded by two oxygen atoms of two phosphonic groups of the bidentately coordinated ligand with closure of six-membered [O, O] ring, and two chlorine anions. The formation of palladium(II) equimolar complexes with PhHMBP and bidentate coordination of the ligand to the central metal cation was confirmed by³¹P NMR spectroscopy. Cytotoxic activity (IC₅₀ based on metal content) of the synthesized Pd(II) complexes with PhHMBP against human MG-63 osteosarcoma and MCF-7 mammary tumor cells was compared with cisplatin on in vitro models. It was established that cytotoxic activity of the Pd complexes was lower than that of cisplatin. The acute toxicity (LD₅₀ based on metal content) of solutions of Pd(II) complexes with PhHMBP was found to be lower compared to cisplatin. It was shown that the use of solutions of palladium(II) complexes with PhHMBP inhibited tumor growth in mice with sarcoma 180
Additional Access Points:
Kozachkova, O. M.
Tsaryk, N. V.
Trachevskyi, V. V.
Rozhenko, A. B.
Shermolovich, Yu. H.
Guzyr, O. I.
Sharykina, N. I.
Chekhun, V. F.
Pekhnyo, V. I.

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Association of CD44⁺CD24^-/low with markers of aggressiveness and plasticity of cell lines and tumors of patients with breast cancer [Text] / V. F. Chekhun [та ін.] // Экспериментальная онкология. - 2017. - Т. 39, № 3. - С. 203-211. - Bibliogr. at the end of the art.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (осложнения, патофизиология, этиология)
НОВООБРАЗОВАНИЙ МАРКЕРЫ БИОЛОГИЧЕСКИЕ -- TUMOR MARKERS, BIOLOGICAL (анализ)
ЦИТОСТАТИЧЕСКИЕ СРЕДСТВА -- CYTOSTATIC AGENTS (анализ, терапевтическое применение)
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ НОВООБРАЗОВАНИЙ -- DRUG RESISTANCE, NEOPLASM (физиология)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To search for additional molecular-biological markers of cancer stem cell (CSC) involved in the development of intra-tumor heterogeneity for the detection of features of the breast cancer (BC) pathogenesis. Materials and methods: Expression of estrogen receptors (ER), progesterone receptors (PR), Her2/neu, E- and N-cadherin, CD24, CD44, Bcl-2, Bax, Slug, P-gp, glutathione-S-transferase (GST) and metallothionein in cell lines was determined by the immunocytochemical method. Expression of ER, PR, Her2/neu, CD24 and CD44 in the surgical material of BC patients were determined by the immunohistochemical method. The levels of the miRNA were determined using real-time polymerase chain reaction. Results: Cells of high-grade malignancy (HGM), MDA-MB-231 and MDA-MB-468 are characterized by high expression of stem cell markers compared to the cells of low-grade malignancy (LGM), T47D and MCF-7: CD44 levels in T47D and MCF-7 cells were in range of 72-79 points, which is significantly lower than in HGM cells (p 0.05). Also, HGM cells with the properties of CSC were characterized by high expression of antiapoptotic proteins, the transcription factor Slug, and low levels of proapoptotic protein Bax (p 0.05) compared to LGM cells. In cells with CSC characteristics an increased expression of transferrin and its receptor, ferritin, fentorin and hepcidin was revealed indicating activation of the endogenous iron metabolism. The characteristic feature of HGM cells with CSC phenotype were the increased levels of oncogenic miR-221, -155 and -10b by 60%, 92% and 78%, respectively, and decreased levels of oncosuppressive miR-29b, -34a and -200b by 8.4 ± 0.3, 4.6 ± 0.2, and 3.4 ± 0.6 times compared to MCF-7 line cells. It has been established that the development of resistance to cytostatics is accompanied by increased aggressiveness of tumor cells, loss of expression of hormonal receptors and acquiring of stem phenotype. In particular, increased expression of P-gp was observed in BC cells during the development of resistance to doxorubicin, of GST during the development of resistance to cisplatin along with increased CD44 expression (p 0.05). We have revealed the relation between the presence of cells with the CSC phenotype (CD44+CD24-/low) and clinical and pathological characteristics of BC patients, their survival and BC sensitivity to neoadjuvant therapy (p > 0.05). Conclusions: The dependence between the expression of CSC markers and the degree of malignancy of tumor cells, development of resistance to cytostatics in vitro was established as well as the predictive value of the detection of the CSC for the individual prognosis of the BC course and sensitivity of the tumors to the treatment
Additional Access Points:
Chekhun, V. F.
Lukianova, N. Y.
Chekhun, S. V.
Bezdieniezhnykh, N. O.
Zadvomiy, T. V.
Borikun, T. V.
Polishchuk, L. Z.
Klyusov, O. M.

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Chekhun, V. F.
On the 40th anniversary of the international symposium “The role of stem cells in leukemo-and carcinogenesis»: in Kyiv again [Text] / V. F. Chekhun // Экспериментальная онкология. - 2017. - Т. 39, № 3. - С. 162-163

MeSH-main:
ЮБИЛЕИ И ДРУГИЕ ВАЖНЫЕ СОБЫТИЯ -- ANNIVERSARIES AND SPECIAL EVENTS
СЪЕЗДЫ, СИМПОЗИУМЫ -- CONVENTIONS, SYMPOSIUMS
СТВОЛОВЫЕ КЛЕТКИ -- STEM CELLS
НЕОПЛАСТИЧЕСКИЕ ПРОЦЕССЫ -- NEOPLASTIC PROCESSES
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Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics / V. F. Chekhun [et al.] // Experimental Oncology. - 2017. - Том 39, N 1. - P25-29 : табл. - 21 ref.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия)
АРТЕМИЗИНИНЫ -- ARTEMISININS
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ -- DRUG RESISTANCE
Annotation: To explore effects of Artemisinin on a series of breast cancer cells with different sensitivity to typical cytotoxic drugs (doxorubicin — Dox; cisplatin — DDP) and to investigate possible artemisinin-induced modification of the mechanisms of drug resistance. Materials and Methods: The study was performed on wild-type breast cancer MCF-7 cell line (MCF-7/S) and its two sublines MCF-7/Dox and MCF-7/DDP resistant to Dox and DDP, respectively. The cells were treated with artemisinin and iron-containing magnetic fluid. The latter was added to modulate iron levels in the cells and explore its role in artemisinin-induced effects. The MTT assay was used to monitor cell viability, whereas changes of expression of selected proteins participating in regulation of cellular iron homeostasis were estimated using immunocytochemical methods. Finally, relative expression levels of miRNA-200b, -320a, and -34a were examined by using qRT-PCR. Results: Artemisinin affects mechanisms of the resistance of breast cancer cells towards both Dox and DDP at sub-toxic doses. The former drug induces changes of expression of iron-regulating proteins via different mechanisms, including epigenetic regulation. Particularly, the disturbances in ferritin heavy chain 1, lactoferrin, hepcidin (decrease) and ferroportin (increase) expression (р ≤ 0.05) were established. The most enhanced increase of miRNA expression under artemisinin influence were found for miRNA-200b in MCF-7/DDP cells (7.1 ± 0.98 fold change), miRNA-320a in MCF-7/Dox cells (2.9 ± 0.45 fold change) and miRNA-34a (1.7 ± 0.15 fold change) in MCF-7/S cells. It was observed that the sensitivity to artemisinin can be influenced by changing iron levels in cells. Conclusions: Artemisinin can modify iron metabolism of breast cancer cells by its cytotoxic effect, but also by inducing changes in expression of iron-regulating proteins and microRNAs (miRNAs), involved in their regulation. This modification affects the mechanisms that are implicated in drug-resistance, that makes artemisinin a perspective modulator of cell sensitivity towards chemotherapeutic agents in cancer treatment
Additional Access Points:
Chekhun, V.F.
Lukianova, N.Y.
Borikun, T.V.
Zadvornyi, T.V.
Mokhir, A.

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Chekhun, V. F.
Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova // Experimental Oncology. - 2017. - Том 39, N 1. - P65-68 : табл. - 16 ref.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (лекарственная терапия)
ХИМИОТЕРАПИЯ АДЪЮВАНТНАЯ -- CHEMOTHERAPY, ADJUVANT
СИМПОРТЕРЫ -- SYMPORTERS
Annotation: The aim of the research was to study the relation between expression of Na⁺/I⁻symporter (NIS) in breast cancer (BC) of different molecular subtypes and sensitivity of BC cells to neoadjuvant chemotherapy (NACT) and to assess whether NIS expression may be used as a predictive marker of treatment efficacy. Materials and Methods: The study included 148 women with BC of stage II–III who were treated at the Precarpathian Clinical Oncology Center during 2012–2017. All patients were treated with NACT that included 2–6 cycles of chemotherapy by FAC, AC scheme with 21 day intervals. NACT efficacy was evaluated every 2 cycles by mammography according to RECIST criteria. Morphological and immunohistochemical study of NIS expression was performed by the standard methods on paraffin sections of surgically resected tumors. Results: The heterogeneity of different molecular BC subtypes regarding response to the NACT has been found. Her2/neu-positive and basal BC subtypes were the least susceptible to the NACT (p 0.05). It was shown that NIS expression is related to the sensitivity of luminal B and basal BC subtypes to the NACT. The highest expression of NIS and impairment of its functional activity was registered in the group of patients with tumors resistant to NACT (stabilization of the disease or its progression) of luminal B (220 ± 8.6 points) and basal subtypes (290 ± 11.3 points) (p 0.05). It was revealed that the disease-free survival of patients with BC of luminal B and basal subtypes was higher in the absence of NIS expression in tumor cells (p 0.05). Conclusions: The results indicate that NIS can be used as an objective criterion for predicting the sensitivity of luminal B and basal BC subtypes to NACT, which will provide improved treatment outcomes in this group of patients
Additional Access Points:
Andriiv, A.V.
Lukianova, N.Yu.

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Cipher: УУ60/2017/89/2
Journal

The Ukrainian biochemical journal [Text]. - Published biomonthly
2017year Т. 89 № 2

Contents:
Shtemenko, A. V. Rhenium-platinum antitumor systems / A. V. Shtemenko, N. I. Shtemenko. - P.5-30
Minchenko, O. H. Effect of chromium disilicide and titanium nitride nanoparticles on the expression of NAMPT, E2F8, FAS, TBX3, IL13RA2, and UPS7 genes in mouse liver / О. Н. Minchenko [et al.]. - P.31-42
Other authors: Yavorovsky O. P., Solokha N. V., Minchenko D. O., Kuznetsova A. Y.
Tykhomyrov, A. A. Plasminogen and its fragments in rat brain: a plausible role for astrocytes in angiostatin generation / A. A. Tykhomyrov [et al.]. - P.43-54
Other authors: Nedzvetsky V. S., Agca C. A., Korsa V. V., Grinenko T. V.
Minchenko, O. H. IRE1 knockdown modifies hypoxic regulation of cathepsins and LONP1 genes expression in U87 glioma cells / О. Н. Minchenko [et al.]. - P.55-69
Other authors: Riabovol О. O., Halkin O. V., Minchenko D. O., Ratushna O. O.
Kaplia, A. A. Different sensitivity of Na+,K+-ATPase and Mg2+-ATPase to ethanol and arachidonic acid in rat colon smooth muscle under pretreatment of cellular membranes with Ds-Na / A. A. Kaplia. - P.70-77
Biliavska, L. O. Sterols biosynthesis by soil streptomycetes / L. O. Biliavska [et al.]. - P.78-84
Other authors: Ostapchuk A. M., Voychuk S. I., Iutynska G. O.
Kosyk, O. I. Phenylalanine ammonia-lyase activity and anthocyanin content in different varieties of lettuce under the cadmium influence / O. I. Kosyk [et al.]. - P.85-91
Other authors: Khomenko I. M., Batsmanova L. M., Taran N. Yu.
Kopylchuk, H. P. Rat liver arginase system under acetaminophen-induced toxic injury and protein deprivation / H. P. Kopylchuk, I. M. Nykolaichuk, O. M. Zhuretska. - P.92-98
Korol, L. V. Intensity of oxidative stress and activity of angiotensin converting enzyme in blood of patients with uncomplicated pyelonephritis / L. V. Korol, L. Ya. Mygal, N. M. Stepanova. - P.99-105
Kozachkova, O. M. Complexes of palladium(II) with 1-phenyl-1-hydroxymethylene bisphosphonic acid and their antitumor activity / O. M. Kozachkova [et al.]. - P.106-115
Other authors: Tsaryk N. V., Trachevskyi V. V., Rozhenko A. B., Shermolovich Yu. H., Guzyr O. I., Sharykina N. I., Chekhun V. F., Pekhnyo V. I.
Ellidag, H. Y. A novel method for negating cold agglutination interference by dithiothreitol during complete blood count and peripheral blood smear: a case study / H. Y. Ellidag [et al.]. - P.116-120
Other authors: Kulaksizoglu S., Eren E., Yilmaz N.
Данилова, В. М. Науково-практична діяльність відділу нейрохімії Інституту біохімії ім. О. В. Палладіна НАН України / В. М. Данилова, Р. П. Виноградова, Г. Г. Луговська. - P.121-134
Вельмишановна та дорога Валентино Михайлівно! (до 80-річчя від дня народження). - P.135
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10.

Cipher: ЕУ12/2017/39/1
Journal

Экспериментальная онкология [Text]
2017year Т. 39 № 1

Contents:
Circulating tumor cells in breast cancer : functional heterogeneity, pathogenetic and clinical aspects. - С.2-11 : il.
Kashuba, E. Do MRPS 18-2 and RB proteins cooperate to control cell stemness and differentiation, preventing cancer development? / E. Kashuba, M. Mushtag. - С.12-16 : цв. ил.
Effect of antitumor drugs in low concentrations on the biological, immunophenotypic and cytogenetic characteristics of human colon cancer cells in vitro. - С.17-24 : цв. ил.
Artemisinin modulating effect on human breast cancer cell lines with different sensitivity to cytostatics. - С.25-29 : табл.
Parthenolide reduces gene transcription of prosurvival mediators in U937 cells. - С.30-35 : il.
Anti-histone H1 IgGs prossess proliferative activity towards human T-leukemia CEM cells. - С.36-41 : il.
Anticancer effect and immunologic response to xenogeneic embryonic proteins in mice bearing Ehrlich solid carcinoma. - С.42-48 : табл.
EPR spectroscopy studies of changes in erythrocyte membranes in patients with laryngeal cancer. - С.49-52 : табл.
Auzina, D. Prognostic value of the bone turnover markers in multiple myeloma / D. Auzina, R. Erts, S. Lejniece. - С.53-56 : табл.
Aberrant promoter hypermethylation of selected apoptotic genes in childhood acute lymphoblastic leukemia among North Indian population. - С.57-64 : табл.
Chekhun, V. F. Significance of iodine symporter for prognosis of the disease course and efficacy of neoadjuvant chemotherapy in patients with breast cancer of luminal and basal subtypes / V. F. Chekhun, A. V. Andriiv, N. Yu. Lukianova. - С.65-68 : табл.
Satinder, K. Impact of single nucleotide polymorphism in chemical metabolizing genes and exposure to wood smoke on risk of cervical cancer in North-Indian women / K. Satinder, R. C. Sobti, K. Pushpinder. - С.69-74 : табл.
The impact of coloregional treatment on survival of patients with primary metastatic breast cancer. - С.75-77 : табл.
Diagnostic challenges with intraoral myeloid sarcoma : Report of two cases & review of world literature. - С.78-85 : цв. ил.
Trichilemmal cystis in metastatic melanoma : A case report. - С.86-87 : цв. ил.
Materials of international vactrain/ 3-rd Swedish-Ukrainian conference on cancer diseases, January 16-17, 2017, Stockholm, Sweden. - С.88-93
Endoplasmic reticulum stress as a key factor of genome reprogramming in cancer cells. - С.88-89
The adaptor protein Ruk/CIN85 paradoxically enhances EMT of triple negative mouse breast adenocarcinoma 4T1 cells. - С.89
Biological characteristics of tumor cells at the different stages of EMT upon exposure to anticancer drugs and cytokines. - С.89-90
Alternative direction of inhibition of malignant properties in tumor cells in vitro and in vivo by gene therapy with INF-beta gene in recombinant baculovirus vector. - С.90
CD150/SLAMF1 as a new potential target for anti-tumor therapy. - С.90-91
CD150/SLAMF1 antigen in molecular pathobiology of chronic lymphocytic leukemia. - С.91-92
Borikun, T. Changes in expression of miRNA-122, -200b, and -320a as prognostic biomarkers for breast cancer / T. Borikun, N. Lukianova, V. Chekhun. - С.92
The MRPS 18-2 protein as a putative marker of carcinogenesis. - С.92
High expression levels of MRPS 18-2 and presence of the RB protein are required for the maintenance of stem cell phenotype. - С.92-93
Mankovska, O. Identification of novel molecular and genetic markers for early detection and prognosis of epithelial tumors / O. Mankovska, V. Kashuba. - С.93
Brieieva, O. Genotoxic sensitivity to 4-hydroxyestradiol in peripheral blood lymphocytes of endometrial cancer patients / O. Brieieva, I. Nesina, L. Buchynska. - С.93
Kyiv, May 11-12, 2017 Workshop with international participation. New trends in cancer research and innovative tumor vaccines. - С.94
International scientific conference "Normal and and cancer stem cells: discovery, diagnosis and therapy", October 5-6, 2017, Kyiv, Ukraine. - С.95
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11.

Grybach, S. M.
Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome [Text] / S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 243-248. - Bibliogr. at the end of the art.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (патофизиология, этиология)
ПОЖИЛЫЕ -- AGED (статистика, физиология)
МЕТАБОЛИЧЕСКИЙ СИНДРОМ X -- METABOLIC SYNDROME X (осложнения, патофизиология, этиология)
ВЫЖИВАЕМОСТИ АНАЛИЗ -- SURVIVAL ANALYSIS
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To analyze the survival of patients with breast cancer (BC) depending on age, molecular subtype of the tumor and the presence of metabolic syndrome. Patients and Methods: We have analyzed the results of examination and treatment of 202 patients with BC of stages I–III. The patients were distributed by age into 2 groups. The group 1 included 86 elderly patients (from 65 to 84 years old), the group 2 — 116 younger patients (from 32 to 64 years). An overall 1-, 3- and 5-year survival rates of the treated patients were assessed. The significance of factors influencing the overall survival (OS) of patients with BC was determined using the methods of statistical analysis. Results: Molecular subtype of BC significantly affects survival rates: in a case of a luminal B subtype the 5-year OS was 71.6 vs 80% (p 0.05) in groups 1 and 2, respectively while in a case of a basal-like subtype it was 60.2% and 71.6% (p 0.05). The presence of metabolic syndrome significantly reduced the 5-year OS (up to 70.7% and 80.6%, p 0.05 in groups 1 and 2, respectively). Conclusion: The OS is lower in elderly patients with BC compared with younger patients, especially in those who suffer from metabolic syndrome. Key Words: breast cancer, elderly age, metabolic syndrome, receptor status, 1-, 3-, 5-year overall survival
Additional Access Points:
Polishchuk, L. Z.
Chekhun, V. F.

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12.

Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats [Text] / V. F. Chekhun [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 200-204. - Bibliogr. at the end of the art.

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (патофизиология, этиология)
КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER (патофизиология, этиология)
ЛАКТОФЕРРИН -- LACTOFERRIN (анализ, метаболизм, терапевтическое применение, физиология)
РОСТА ИНГИБИТОРЫ -- GROWTH INHIBITORS (анализ, диагностическое применение)
МУТАГЕНЫ -- MUTAGENS (анализ)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To investigate the influence of exogenous lactoferrin (LF) on tumor growth, energy and lipid metabolism of Walker-256 carcinosarcoma and to assess genotoxic effects of LF. Materials and Methods: The study was performed on Walker-256 tumor-bearing rats. Total lipids and phospholipids were determined by thin-layer chromatography. Comet assay was used to investigate the genotoxic effects of LF. Results: Daily i.p. administrations of exogenous LF at concentrations of 1 mg/kg and 10 mg/kg starting from the 4th day after tumor transplantation suppressed growth of Walker-256 carcinosarcoma by almost 44%. After treatment with recombinant LF in both doses, the phospholipid composition of Walker-256 carcinosarcoma cells was changed (3-fold increase of phosphatidylethanolamine, 3.4-fold increase of phosphatidylcholine, and 1.8-fold increase of sphingomyelin, while the cardiolipin content decreased by 67%. Exogenous LF was not genotoxic for bone marrow cells (as assessed by the ratio of PCE/NCE, number of micronuclei) and peripheral blood lymphocytes (percentage of DNA in the tail of a comet) in Walker-256 carcinosarcoma-bearing rats. Conclusion: Exogenous LF caused the inhibition of Walker-256 carcinosarcoma growth and a decrease in the microviscosity of plasma cell membranes, and exerted no genotoxicity toward bone marrow cells and peripheral blood of experimental animals. Key Words: lactoferrin, breast cancer, Walker-256 carcinosarcoma, phospholipid content, genotoxicity
Additional Access Points:
Chekhun, V. F.
Storchai, D. M.
Todor, I. N.
Borikun, T. V.
Lukianova, N. Yu.

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13.

Cipher: ЕУ12/2018/40/3
Journal

Экспериментальная онкология [Text]
2018year Т. 40 № 3

Contents:
Akbarzadeh, A. Role of dendrimers in advanced drug delivery and biomedical applications: a review / A. Akbarzadeh [та ін.]. - С.178-183. - Bibliogr. at the end of the art.
Other authors: Khalilov R., Mostafavi E., Annabi N., Abasi E., Kafshdooz T., Herizchi R., Kavetskyy T., Saghfi S., Nasibova A., Davaran S.
Zadvornyi, T. V. Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro / T. V. Zadvornyi [та ін.]. - С.184-189. - Bibliogr. at the end of the art.
Other authors: Lukianova N. Y., Borikun T. V., Chekhun V. F.
Harper, P. The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: in vitro studies / P. Harper [та ін.]. - С.190-193. - Bibliogr. at the end of the art.
Other authors: Hald O., Lwaleed B. A., Kyyaly A., Johnston D., Cooper A. J., Birch B.
Apykhtina, О. L. Cytotoxic and genotoxic effects of cadmium sulfide nanoparticles / О. L. Apykhtina [та ін.]. - С.194-199. - Bibliogr. at the end of the art.
Other authors: Dybkova S. M., Sokurenko L. M., Chaikovsky Yu. B.
Chekhun, V. F. Antitumor and genotoxic effects of lactoferrin in Walker-256 tumor-bearing rats / V. F. Chekhun [та ін.]. - С.200-204. - Bibliogr. at the end of the art.
Other authors: Storchai D. M., Todor I. N., Borikun T. V., Lukianova N. Yu.
Prokhorova, I. V. Influence of metformin, sodium dichloroacetate and their combination on the hematological and biochemical blood parameters of rats with gliomas C6 / I. V. Prokhorova [та ін.]. - С.205-210. - Bibliogr. at the end of the art.
Other authors: Pyaskovskaya O. N., Kolesnik D. L., Solyanik G. I.
Abramenko, I. V. Analysis of the 3′UTR region of the NOTCH1 gene in chronic lymphocytic leukemia patients / I. V. Abramenko [та ін.]. - С.211-217. - Bibliogr. at the end of the art.
Other authors: Bilous N. I. , Chumak A. A., Dyagil I. S., Martina Z. V.
Nesina, I. P. Markers of the epithelial-mesenchymal transition in cells of endometrial carcinoma / I. P. Nesina, N. P. Iurchenko, L. G. Buchynska. - С.218-222. - Bibliogr. at the end of the art.
Vernygorodskyi, S. Comparative histochemical evaluation of mucins expression in fetal esophagus and adenocarcinomas of the gastroesophageal junction / S. Vernygorodskyi, T. Rekun, P. Zhuchenko. - С.223-227. - Bibliogr. at the end of the art.
Gerashchenko, T. S. Different morphological structures of breast tumors demonstrate individual drug resistance gene expression profiles / T. S. Gerashchenko [та ін.]. - С.228-234. - Bibliogr. at the end of the art.
Other authors: Denisov E. V., Novikov N. M., Tashireva L. A., Kaigorodova E. V., Savelieva O. E., Zavyalova M. V., Cherdyntseva N. V., Perelmuter V. M.
Agishev, T. T. Determination of oxygen perfusion in the area of radiation-induced fibrosis of the skin in patients with breast cancer and its role in pathogenesis of late radiation injury / T. T. Agishev [та ін.]. - С.235-238. - Bibliogr. at the end of the art.
Other authors: Topuzov E. E., Кrasnozhon D. A., Petrachkov A. O., Pavlov R. V., Doniyarov S. H.
Dumansky, Yu. V. Paraneoplastic syndrome in lung cancer / Yu. V. Dumansky [та ін.]. - С.239-242. - Bibliogr. at the end of the art.
Other authors: Syniachenko O. V., Stepko P. A., Yehudina Ye. D., Stoliarova O. Yu.
Grybach, S. M. Analysis of the survival of patients with breast cancer depending on age, molecular subtype of tumor and metabolic syndrome / S. M. Grybach, L. Z. Polishchuk, V. F. Chekhun. - С.243-248. - Bibliogr. at the end of the art.
Chrysanthakopoulos, N. A. ABO blood group and the risk of lung cancer in Greek adults: a case — control study / N. A. Chrysanthakopoulos, N. S. Dareioti. - С.249-250. - Bibliogr. at the end of the art.
Tkachenko, R. A case report of late local relapse of adrenocortical carcinoma 18 years after adrenalectomy / R. Tkachenko, A. Golovko, O. Kuryk. - С.251-253
Svitlana Pavlivna Sidorenko (1953–2018). - С.254-255
Yurii Yosypovych Kudryavets (1946–2018). - С.256-257
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14.

Effects of exogenous lactoferrin on phenotypic profile and invasiveness of human prostate cancer cells (DU145 and LNCaP) in vitro [Text] / T. V. Zadvornyi [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 3. - С. 184-189. - Bibliogr. at the end of the art.

MeSH-main:
ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- PROSTATIC NEOPLASMS (патофизиология, этиология)
ЛАКТОФЕРРИН -- LACTOFERRIN (анализ, терапевтическое применение, фармакология)
ТКАНЕЙ ВЫЖИВАЕМОСТЬ -- TISSUE SURVIVAL (действие лекарственных препаратов)
ИММУНОГИСТОХИМИЯ -- IMMUNOHISTOCHEMISTRY (использование, тенденции)
ГЕННОЙ ЭКСПРЕССИИ РЕГУЛЯЦИЯ -- GENE EXPRESSION REGULATION (действие лекарственных препаратов)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To investigate the biological effects of exogenous lactoferrin (LF) on phenotypic profile and invasiveness of human prostate cancer (PC) cells in vitro. Materials and Methods: Human PC cell lines (LNCaP, DU-145) were cultured with an exogenous LF at a dose corresponding to IC30. The expression levels of steroid hormone receptors (androgen receptor, estrogen receptor, progesterone receptor), Her2/neu, Ki-67, E- and N-cadherin, were monitored by immunohistochemical analysis. The levels of miRNAs were assessed using q-PCR. The invasive activity of the cells was examined in a standard invasion test. Results: Exogenous LF reduced expression of steroid hormone receptors (ERα and PR) and Ki-67 in both PC cell lines. The expression of E-cadherin increased significantly in LF-treated DU-145 cells. Also, we established the decrease in invasive activity upon LF treatment by 40% and 30% in DU-145 and LNCaP cells, respectively. In DU-145 cells, incubation with exogenous LF resulted in an increase in the expression of oncosuppressive (miR-133a and miR-200b) miRNAs. Conclusions: Exogenous LF causes the changes in phenotypic characteristics of PC cells and levels of oncogenic and oncosuppressive miRNAs involved in the regulation of key cellular processes. Key Words: prostate cancer, exogenous lactoferrin, DU145, LNCaP, miRNA
Additional Access Points:
Zadvornyi, T. V.
Lukianova, N. Y.
Borikun, T. V.
Chekhun, V. F.

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15.

Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer [Text] / O. V. Paliychuk [та ін.] // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 59-67. - Bibliogr. at the end of the art.

MeSH-main:
НОВООБРАЗОВАНИЯ -- NEOPLASMS (врожденный)
РЕПРОДУКТИВНОЕ ЗДОРОВЬЕ -- REPRODUCTIVE HEALTH (тенденции)
ЖЕНЩИН ЗДОРОВЬЕ -- WOMEN'S HEALTH (тенденции)
ЛИНЧА СИНДРОМ II -- LYNCH SYNDROME II (диагностика, патофизиология, этиология)
ГЕНЫ СУПРЕССОРЫ ОПУХОЛЕВОГО РОСТА -- GENES, TUMOR SUPPRESSOR
ГЕНЫ BRCA1 -- GENES, BRCA1 (физиология)
ГЕНЫ BRCA2 -- GENES, BRCA2 (физиология)
МУТАЦИЯ -- MUTATION (физиология)
РИСКА СТЕПЕНИ ОЦЕНКА -- RISK ADJUSTMENT (использование, статистика, тенденции)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
Annotation: To develop a prognostic molecular genetic model for assessing the risk of development of benign and malignant tumors of female reproductive organs (FRO) in patients from cancer-affected families. Patients and Methods: The work presents the data on a comprehensive clinical examination of 210 women (90 patients with FRO cancer with aggregation of tumor pathology in families, 65 patients with benign pathology of FRO from cancer-affected families, 55 women — control group of healthy women without family history of cancer). Clinical genealogical analysis, morphological examination of tumors and molecular genetic studies of genomic DNA from peripheral blood and tumors were carried out. Results: It was established that in the families of patients with benign and malignant pathology of FRO, malignant tumors associated with Lynch II syndrome are observed. Based on the analysis of detected ESR-1, CYP 2D6*4 and mutations in BRCA1/2 genes in cancer patients and in patients with benign pathology, molecular genetic models have been developed to assess the individual risk of development of benign and malignant tumors of FRO. It has been established that these molecular genetic models and combinations of gene mutations and gene polymorphisms (SNP) by the intergene interaction that was analyzed, were found to be reliable in assessing the risk of benign and malignant pathology of the mammary gland and ovary. Conclusions: The model, which included the polymorphic variants of the T397C(ESR1)/CYP 2D6*4 genes was of the best predictive accuracy for the evaluation of the risk of benign tumors of the FRO (71.68%) and the highest reliability (p 0.001). At the same time, all identified models of intergene interaction in the development of malignant pathology of FRO were reliable, prognostically significant with high reproduction and almost identical accuracy (65.00–68.23%). The obtained results indicate a high informativeness of such molecular genetic indices as the polymorphism of ESR1 and CYP 2D6*4 genes and mutations in BRCA1/2 genes to assess the risk of benign or malignant tumors of FRO in families of patients with family history of cancer
Additional Access Points:
Paliychuk, O. V.
Polishchuk, L. Z.
Rossokha, Z. I.
Chekhun, V. F.

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16.

Cipher: ЕУ12/2018/40/1
Journal

Экспериментальная онкология [Text]
2018year Т. 40 № 1

Contents:
Kian, R. Role of components of microRNA machinery in carcinogenesis / R. Kian, S. Moradi, S. Ghorbian. - С.2-9. - Bibliogr. at the end of the art.
Patel, K. R. Clinical implications of p53 alterations in oral cancer progression: a review from India / K. R. Patel [та ін.]. - С.10-18. - Bibliogr. at the end of the art.
Other authors: Vajaria B. N., Singh R. D., Begum R., Patel P. S.
Varela-Castillo, O. Characterization of the cytotoxic effects of the combination of cisplatin and flavanol (-)-epicatechin on human lung cancer cell line A549. An isobolographic approach / O. Varela-Castillo [та ін.]. - С.19-23. - Bibliogr. at the end of the art.
Other authors: Cordero P., Gutierrez-Iglesias G., Palma I., Rubio-Gayosso I., Meaney E., Ramirez-Sanchez I., Villarreal F., Ceballos G., Najera N.
Chaves, K. C. B. Impact of endostatin gene therapy on myeloid-derived suppressor cells from a metastatic renal cell carcinoma / K. C. B. Chaves [та ін.]. - С.24-32. - Bibliogr. at the end of the art.
Other authors: Costa E. M., Teixeira L. F., Bellini M. H.
Sarnatskaya, V. V. Highly activated carbon enterosorbent mediates the suppression of paraneoplastic syndrome associated with lewis lung carcinoma in mice / V. V. Sarnatskaya [та ін.]. - С.33-41. - Bibliogr. at the end of the art.
Other authors: Sakhno L. A., Paziuk L. M., Yushko L. A., Rodionova N. K., Maslenny V. N., Sydorenko A. S., Nikolaev V.G.
Boroday, N. V. Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells / N. V. Boroday, V. F. Chekhun. - С.42-47. - Bibliogr. at the end of the art.
Kurtenkov, O. Signatures of anti-Thomsen — friedenreich antigen antibody diversity in colon cancer patients / O. Kurtenkov, M. Bubina, K. Klaamas. - С.48-58. - Bibliogr. at the end of the art.
Paliychuk, O. V. Molecular-genetic models for prognosis of development of tumors of reproductive system in women with family history of cancer / O. V. Paliychuk [та ін.]. - С.59-67. - Bibliogr. at the end of the art.
Other authors: Polishchuk L. Z., Rossokha Z. I., Chekhun V. F.
Buchynska, L. G. Sensitivity to 4-hydroxyestradiol and dna repair efficiency in peripheral blood lymphocytes of endometrial cancer patients / L. G. Buchynska, O. V. Brieieva. - С.68-72. - Bibliogr. at the end of the art.
Lozynska, L. Y. Variant of rare hermansky — pudlak syndrome associated with granulomatous colitis: diagnostics clinical course and treatment / L. Y. Lozynska [та ін.]. - С.73-78. - Bibliogr. at the end of the art.
Other authors: Plawski A., Lozynska M. R., Vytvytskyi I., Lozynskyi R. Y., Prokopchuk N., Tretiak B.
Zubenko, O. S. Effect of cytostatic agents on expression levels of human beta-defensins-1-4 in A431 and MCF-7 cell lines / O. S. Zubenko [та ін.]. - С.79-81. - Bibliogr. at the end of the art.
Other authors: Semeniuk D. O., Starenka I. O., Pogribnyy P. V.
Imaniar, R. Mediastinal yolk sac tumor infiltrating the heart / R. Imaniar [та ін.]. - С.82-84. - Bibliogr. at the end of the art.
Other authors: Syahruddin E., Soepandi P. Z., Putra A. C., Nurwidya F.
Ben, Kridis W. A long survival of a patient with brain metastasis of unknown site of the primary tumor / Kridis W. Ben [та ін.]. - С.85-87. - Bibliogr. at the end of the art.
Other authors: Sghaier S., Toumi N., Boudawara Z., Khanfir A., Daoud J., Frikha M.
Symposium and Summer School “Fundamental principles of cancer biotherapy” Kyiv Ukraine May 21-24 2018. - С.88
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17.

Boroday, N. V.
Morphological features of doxorubicin-resistant Walker 256 carcinosarcoma and response of mast cells [Text] / N. V. Boroday, V. F. Chekhun // Экспериментальная онкология. - 2018. - Т. 40, № 1. - С. 42-47. - Bibliogr. at the end of the art.

MeSH-main:
КАРЦИНОМА 256 УОКЕРА -- CARCINOMA 256, WALKER (осложнения, патофизиология, терапия, ультраструктура, этиология)
ЛЕКАРСТВЕННАЯ УСТОЙЧИВОСТЬ НОВООБРАЗОВАНИЙ -- DRUG RESISTANCE, NEOPLASM (физиология)
ТУЧНЫЕ КЛЕТКИ -- MAST CELLS (ультраструктура, физиология)
ДОКСОРУБИЦИН -- DOXORUBICIN (анализ)
СТАТИСТИЧЕСКАЯ ОБРАБОТКА ДАННЫХ -- DATA INTERPRETATION, STATISTICAL
ФОТОГРАФИЧЕСКИЕ СНИМКИ -- PHOTOGRAPHS
Annotation: The mechanisms of drug resistance of cancer have not been yet elucidated in details. Recently, the role of mast cells (MCs) in the development of drug resistance has been brought in the limelight. The aim of the study was to examine the morphological features of doxorubicin (DOX)-resistant Walker 256 carcinosarcoma and to assess the response of MCs and histamine content in these cells in relation to the development of resistance to DOX as well as in DOX-resistant tumors. Materials and Methods: The DOX resistance was induced by serial passages of Walker 256 carcinosarcoma in rats in the setting of DOX treatment in vivo. MCs in tumors were detected in the sections by staining with Toluidine Blue O. Histamine content in MCs stained with solution of Water Blue-Orcein was assessed by Astaldi semiquantitative method taking into account different staining intensity. Results: Formation of DOX resistance in the course of serial passages of Walker 256 carcinosarcoma was accompanied by the increase in the number of MCs in tumors and histamine content. Nevertheless, in tumors with phenotype of complete DOX resistance the number of histamine-containing MCs decreased to the same level as in tumors of the original strain that are DOX-sensitive. Conclusion: MCs are involved in formation of DOX resistance in Walker 256 carcinosarcoma
Additional Access Points:
Chekhun, V. F.

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18.

Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.] // Experimental Oncology. - 2018. - Том 40, N 4. - P268-274

MeSH-main:
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯ -- BREAST NEOPLASMS (метаболизм, патофизиология)
Annotation: To study the effect of Ferroplat (FrP) on the indexes of pro/antioxidant balance and energy metabolism in breast cancer cells of different malignancy degree and different sensitivity to drug therapy. Materials and Methods: The study was carried out on breast cancer cells of low (T47D, MCF-7) and high malignancy degree (MCF-7/DDP (cisplatin-resistant), MDA-MB-231, MDA-MB-468) using cell culture techniques, immunocytochemical, biochemical, biophysical methods, flow cytometry and polarography. Results: We established that the addition of FrP to the culture medium reduces the activity of glucose-6-phosphate dehydrogenase (G6PDH), superoxide dismutase (SOD) and the level of non-protein thiols by 32–41% (p 0.05). At the same time, there was an increase of the total level of ROS and the rate of NO generation by inducible NO synthase by 1.7–2.5 times (p 0.05). This testifies that FrP disturbs the antioxidant balance in cells, resulting in their death. Also, the use of FrP led to a decrease in the rate of oxygen absorption in MCF-7 and T47D cells by 26% and 25%, respectively (p 0.05). In cells of high malignancy degree this index decreased by 38–40% under the influence of FrP. Incubation of MCF-7 and T47D cells with the indicated agent also reduced the content of phospholipid cardiolipin by 15–16% (p 0.05), and in MDA-MB-231, MCF-7/DDP, MDA-MB-468 cells — by 29%, 30% and 32%, respectively. In addition, the effect of FrP caused a decrease in the levels of Mg2+ and lactate in MCF-7 and T47D cells by 21–29% and 14–24%, respectively, whereas in MDA-MB-231, MDA-MB-468, MCF-7/DDP cells — by 34–38% and 32–35%, respectively. In this case, the agent raised the level of glucose in the cells of low malignancy degree by 20–23% (p 0.05), and in the cells of high malignancy degree and with the phenotype of drug resistance — by 31–36%. However, the nanocomposite did not affect the activity of lactate dehydrogenase in all studied breast cancer cells. Conclusion: The study has shown that FrP has an effect on the pro/antioxidant balance and energy metabolism of cancer cells. In addition, the denoted effect of FrP was more pronounced in the breast cancer cells with a high malignancy degree and the phenotype of drug resistance
Additional Access Points:
Chekhun, V. F.
Todor, I. N.
Lukianova, N. Yu.
Horbyk, D. M.
Lozovskaya, Yu. V.
Burlaka, A. P.
Borikun, T. V.

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19.

Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F. Chekhun // Experimental Oncology. - 2018. - Том 40, N 4. - P258-260

MeSH-main:
ОНКОЛОГИЯ МЕДИЦИНСКАЯ -- MEDICAL ONCOLOGY (организация и управление, тенденции)
АКАДЕМИИ И ИНСТИТУТЫ -- ACADEMIES AND INSTITUTES (история, организация и управление, тенденции)
УКРАИНА -- UKRAINE
Annotation: Fluctuation of time is determined by the order and sequence of historical events of global and/or local scale, the harmonization of which reflects the dynamics of the development of society. The top of universal values of this process was and remains the academic science, which is based on the principles of an inextricable triad: education, science and culture. The intellectual and creative “explosion” of the 20th and the beginning of the 21st century has fundamentally changed human consciousness and priority values. Along with the knowledge of physical, natural phenomena and the search for energy sources, man has become not only a subject, but also an object of research. The pace of development of the life sciences reached the apogee. The struggle for higher expectancy and quality of life is a priority of modern science. The key problem of biomedical research has been and remains malignant neoplasms, which dynamics becomes a threat of civilizational scale
Additional Access Points:
Chekhun, V. F. \ed.\

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20.

Cipher: ЕУ12/2018/40/4
Journal

Экспериментальная онкология [Text]
2018year Т. 40 № 4

Contents:
Oncology in the mainstream of the National academy of sciences of Ukraine: to the 100th anniversary of the academy / ed. V. F Chekhun. - С.258-260
Tari, K. The role of the genetic abnormalities, epigenetic and microRNA in the prognosis of chronic lymphocytic leukemia / K. Tari [et al.]. - С.261-267
Other authors: Shamsi Z., Ghafari H. R., Atashi A., Shahjahani M., Abroun S.
Chekhun, V. F. Influence of ferromagnetic nanocomposite (ferroplat) on human breast cancer cells of different malignancy degrees: pro/antioxidant balance and energy metabolism / V. F. Chekhun [et al.]. - С.268-274
Other authors: Todor I. N., Lukianova N. Yu., Horbyk D. M., Lozovskaya Yu. V., Burlaka A. P., Borikun T. V.
Symchych, T. V. The effects of early postoperative immunization with xenogeneic embryo proteins on Lewis lung carcinoma model / T. V. Symchych [et al.]. - С.275-281
Other authors: Fedosova N. I., Karaman O. M., Voyeykova I. M., Didenko G. V.
Yakymenko, I. Oxidative and mutagenic effects of low intensity GSM 18OO MHz microwave radiation / I. Yakymenko [et al.]. - С.282-287
Other authors: Burlaka A., Tsybulin O., Brieieva O., Buchynska L., Tsehmistrenko S., Chekhun V.
Smal, M. P. Ber gene polymorphisms associated with key molecular events in bladder cancer / M. P. Smal [et al.]. - С.288-298
Other authors: Kuzhir T. D., Savina N. V., Nikitchenko N. V., Rolevich A. I., Krasny S. A., Goncharova R. I.
Abooshahab, R. Serum level dipeptidyl peptidase-4 as a potential biomarker for medullary thyroid cancer / R. Abooshahab [et al.]. - С.299-302
Other authors: Niyazi E., Yaghmaie P., Chadaksaz H. G., Hedayati M.
Buchynska, L. G. Overexpression of the mitochondrial ribosomal protein S 18-2 in the invasive breast carcinomas / L. G. Buchynska [et al.]. - С.303-308
Other authors: Iurchenko N. P., Kashuba E. V., Brieieva O. V., Glushchenko N. M., Mints M., Lukianova N. Yu., Chekhun V. F.
Arabpour, F. FoxP3 gene polymorphism is associated with breast cancer in iranian patients / F. Arabpour [et al.]. - С.309-314
Other authors: Shafizad A., Rahimzadeh M., Norouzian M., Naderi N.
Gerashchenko, G. V. Expression pattern of genes associated with tumor microenvironment in prostate cancer / G. V. Gerashchenko [et al.]. - С.315-322
Other authors: Grygoruk O. V., Kononenko O. A., Gryzodub O. P., Stakhovsky E. O., Kashuba V. I.
Tas, F. Clinical significance of serum caveolin-1 levels in gastric cancer patients / F. Tas [et al.]. - С.323-327
Other authors: Karabulut S., Erturk K., Duranyildiz D.
Shvachko, L. P. Vitamin E activates expression of C/EBP alpha transcription factor and G-CSF receptor in leukemic K562 cells / L. P. Shvachko [et al.]. - С.328-331
Other authors: Zavelevich M. P., Gluzman D. F., Kravchuk I. V., Telegeev G. D.
Kuzyk, P. V. Rare case of nodular lymphoid hyperplasia of left lung in the patient with previous pulmonary tuberculosis / P. V. Kuzyk, M. A. Savchyna, S. G. Gychka. - С.332-335
Zakhartseva, L. M. Metastatic cardiac tumors: literature review and own observation of testicular tumor metastasis in the right ventricle of the heart / L. M. Zakhartseva [et al.]. - С.336-342
Other authors: Zakharova L. P., Shatrova K. M., Chitaeva G. E., Vitovsky R. M.
Langabeer, S. E. The JAK2 V617F mutation in lung cancer: caveat emptor / S. E. Langabeer. - С.343-344
Professor Volodymyr Oleksiiovych Shlyakhovenko (on the 80th birth anniversary). - С.345
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